Standard BioTools

This year, groundbreaking #ImagingMassCytometry research has taken our understanding of complex diseases and therapies to new heights. Here's what caught our attention!   📄Spatial and Single-Nucleus Analysis of Alzheimer’s Disease: https://lnkd.in/gwekHbi4 The Nature Genetics paper on spatial and single-nucleus transcriptomic analysis revealed critical insights into genetic and sporadic forms of Alzheimer's disease, showcasing the power of #SpatialProteomics in advancing transcriptomics research.   📄Reducing CAR T Therapy Neurotoxicity: https://lnkd.in/gsTwcSfr Nature Cancer highlighted a pivotal study on how targeting TGFβ-activated kinase-1 in microglia reduces neurotoxicity linked to CAR T-cell therapy. Imaging Mass Cytometry (IMC) provided valuable spatial context in brain samples, underscoring the importance of #proteomics in understanding therapy side effects. 

We’re proud to be able to contribute to the great work Emily’s House does to support families. Working with their team is an absolute privilege, and we’re grateful to play a small part in their meaningful mission.   To learn more about Emily's House and how they bring care, support, and smiles to families during challenging times, visit their website here: https://paceh.ca/.

By combining the single-cell analysis approach of #flowcytometry with the precision of #massspectrometry, #masscytometry enables high-parameter analysis while generating little to no signal overlap. This eliminates the need to correct fluorescence spillover and further enables the use of statistical techniques to facilitate screening drug candidates and assessing on- or off-target effects post-treatment. See how it works and learn more about this high-parameter tool: https://lnkd.in/gaNwsnYH

🧬We have an exciting live webinar to add to your 2025 calendar! Explore the role of spatial biology in unraveling the heterogeneity of pancreatic ductal adenocarcinoma from mouse tissue to human samples. Join us for "Bridging the Gap: Insights from Mouse and Human Models in Pancreatic Cancer Research" featuring guest speaker Marco Erreni, PhD from Humanitas Research Hospital!   What you'll learn: ✅ How Imaging Mass Cytometry™ (IMC™) helps assess cell abundance, distribution, and phenotypes in PDAC progression across murine models. ✅ The use of IMC to analyze 8 human PDAC tissues, uncovering insights into cancer-associated fibroblast clusters and molecular pathways. ✅ How integrating mouse and human model analyses provides a comprehensive understanding of tumor-immune-stroma interactions to shape future therapies.   Date: Wednesday, January 22 08:00 PT | 11:00 ET | 16:00 GMT | 17:00 CET   Register now: https://lnkd.in/esUcZK_V #SpatialBiology #CancerResearch #Cytometry #IMC

#Livercancer is the third leading cause of cancer-related mortality worldwide. To improve immunotherapy response rates, the ability to accurately identify responders from non-responders is crucial. Scientists from Huazhong University of Science and Technology used single-cell CyTOF™ technology and mIHC analyses to generate a comprehensive and dynamic immunological atlas associated with response and prognosis in advanced liver cancer patients who underwent treatment with immune checkpoint inhibitors. #CyTOF assisted in identifying predictive and prognostic #biomarkers based on three baseline characterizations in a cohort of 24 patients, supporting patient stratification and fostering new response monitoring strategies. Xue et al. 2024: https://lnkd.in/dVEHmETC

This week, we're in Marseille! 🌅 Join us at the AFC Association Française de Cytométrie Event from December 17-19. Explore how Imaging Mass Cytometry is unlocking new views in spatial biology.   If you're in attendance, stop by booth 51 and visit our poster "Enabling Rapid and Convenient Human Immune Profiling in Fresh and Long-Term Stabilized Whole Blood Samples with CyTOF." We hope to see you there! Aurélie Bouchareine Guilhem RIAL Matthieu Chéné Milosav BOTELLA #SpatialBiology #ImagingMassCytometry #AFC2024 

Mass cytometry is advantageous because of its ability to precisely and accurately distinguish between reporter molecules. By using atomic mass measurements, mass cytometry avoids autofluorescence signals from cells and tissues, enables fast panel design since all antibodies are used at once and facilitates barcoding to multiplex samples in large-scale acquisitions. Learn more about this high-parameter tool and read case studies of its use in clinical trials: https://lnkd.in/gaNwsnYH #MassCytometry #Cytometry #Proteomics

📢 Attending the European Society for Spatial Biology (ESSB) e.V. meeting in Berlin? We are hosting a lunch symposium today! We hope to see you there.   Topic: Whole Slide Imaging Modes for Imaging Mass Cytometry Reveal Cellular Diversity of the Tumor Immune Microenvironment in Mouse Glioblastoma 🗓 Date: Friday, December 13 ⏰ Time: 1:30 – 2:00 PM Add this to your calendar: https://lnkd.in/evFfJUx8   You can also stop by booth 12! Meet the team, explore cutting-edge insights, and connect with experts pushing the boundaries of spatial biology. Anne-Sophie THOMAS-CLAUDEPIERRE Melissa Klug Gunnar Kaiser-Schulz Roberto Spada #SpatialBiology #TumorMicroenvironment #EuropeanSocietySpatialBiology

🎉Wow! What a remarkable year it has been for events in 2024! We've participated in a series of extraordinary events that have brought together brilliant minds and sparked inspiring conversations. Events like #CYTO2024, #AACR2024, #APHL2024, #SITC2024, and many more! The energy was unmatched, and the interest from so many attendees was truly amazing. To all those who joined us—thank you for bringing your passion and insights to the table. Events like these foster collaboration and push the boundaries of research. A big thank you to our amazing team as well, we couldn't have done it without you! We eagerly look forward to what the future holds for next year! 2025 is already shaping up to be even more exciting, so stay tuned 👀

In Bristol Bay, AK, the story of DNA genotyping is one of cultural preservation and community empowerment. For centuries, indigenous communities have relied on the abundant sockeye salmon runs for sustenance and cultural heritage. Today, DNA technology aids in safeguarding this tradition by enabling sustainable management practices that align with traditional knowledge. Standard BioTools is proud to support these communities and their invaluable role in conservation efforts, optimizing fishing efforts and ensuring that harvests are sustainable and protecting salmon populations for future generations. Learn more about the project and watch the whole video here: https://lnkd.in/gbTYvSSb #sustainability