Everand Logo

Welcome to Everand!

  • Discover millions of ebooks, audiobooks, and so much more with a free trial

    From $11.99/month after trial. Cancel anytime.

    Abnormal High Fever (Malignant Hyperthermia), A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
    Abnormal High Fever (Malignant Hyperthermia), A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
    Abnormal High Fever (Malignant Hyperthermia), A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
    Ebook78 pages41 minutes

    Abnormal High Fever (Malignant Hyperthermia), A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions

    By Kenneth Kee

    ()

    Read preview

    About this ebook

    This book describes Abnormal High Fever, Diagnosis and Treatment and Related Diseases
    Malignant hyperthermia (or abnormal high fever) is an genetic disorder that produces a rapid increase in body temperature (fever) and severe muscle contractions (myalgia) when the affected person is provides with general anesthesia.
    This disorder is not the same as hyperthermia due to medical emergencies such as heat stroke.
    This is a rapid rise in temperature normally activated by an anesthetic and tends to be lethal
    It is an inherited myopathy caused by a genetic mutation.
    Linkage studies reveal that in the majority of families the defect is in the ryanodine receptor gene (RYR1) at chromosome 19q13.1
    Malignant hyperthermia is an autosomal dominant trait, indicating it needs only one parent carrying the disorder for a child to inherit the disorder.
    It may be linked with muscular diseases such as multi-mini-core myopathy and central core disease.
    A form of malignant hyperthermia is produced by a defect in the ryanodine receptor (RYR1) gene
    Malignant hyperthermia (MH) reactions happen with the onset postponed for several hours into anesthesia using:
    1. Halothane especially,
    2. Desflurane,
    4. Sevoflurane, and
    5. Isoflurane
    It has been limked with:
    1. Myotonia congenita
    2. Duchenne muscular dystrophy and
    3. Becker's muscular dystrophy.
    Non-depolarizing neuromuscular blockers such as pancuronium are harmless.
    Nitrous oxide and barbiturates such as thiopental are safe.
    Symptoms are:
    1. Rapid rise in temperature to 105 degrees F or higher
    2. Muscle rigidity and stiffness
    3. Dark brown urine (myoglobulin)
    4. Muscle ache without obvious exercise to explain sore muscles
    Onset may be during or within a few hours after anesthesia.
    Spasm of the masseter muscle is often first noted.
    There is muscular rigidity despite a paralyzing agent
    There is tachycardia and the skin is flushed.
    There is hypoxia, hyper-capnea and a metabolic acidosis.
    Temperature may rise above 40° but normo-thermia does not exclude the condition.
    Diagnosis:
    There can be a family history of malignant hyperthermia or non-explained death during anesthesia.
    Genetic testing is used to institute a diagnosis, but the caffeine halothane contracture test (CHCT) is the criterion standard.
    Diagnosis is made by the muscle biopsy.
    Caffeine, halothane, succinylcholine and raised potassium induce amplified contractions.
    DNA testing cannot be used as the only test for MH susceptibility
    Treatment
    For an episode of malignant hyperthermia, a cooling blanket can help reduce fever.
    The treatment with a drug called dantrolene throughout events of malignant hyperthermia has largely decreased the number of deaths.
    Dantrolene, the antidote, decreases the loss of calcium from the sarcoplasmic reticulum in the skeletal muscle and restores normal metabolism
    Fluids given orally and intravenously, and certain medicines, are important for maintaining the kidney function during an acute episode.
    1.Call for help, as management can be difficult and complex for one person.
    2.Switch from volatile anesthetics to alternative forms of anesthesia.
    3.Give 100% oxygen and adjust ventilation according to blood gas analysis and end expiratory pCO2.
    4.Deepen anesthesia with opioids, benzodiazepines, barbiturates or propofol.
    5.Monitor blood gases, electrolytes, CK, myoglobin and lactate.
    6.Stop surgery if it is elective and if there are signs of masseter spasm or a fulminant crisis.
    7.Continue surgery, if there is no hyper-kalemia, no acidosis and there are no triggers.
    8.Intravenous dantrolene should be given but prophylactic administration of dantrolene is now regarded as obsolete.
    9.Arrhythmia may be treated with a beta-blocker or lidocaine.
    TABLE OF CONTENT
    Introduction
    Chapter 1 Abnormal High Fever
    Chapter 2 C

    LanguageEnglish
    PublisherKenneth Kee
    Release dateNov 9, 2017
    ISBN9781370789993
    Abnormal High Fever (Malignant Hyperthermia), A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
    Author

    Kenneth Kee

    Medical doctor since 1972.Started Kee Clinic in 1974 at 15 Holland Dr #03-102, relocated to 36 Holland Dr #01-10 in 2009.Did my M.Sc (Health Management ) in 1991 and Ph.D (Healthcare Administration) in 1993.Dr Kenneth Kee is still working as a family doctor at the age of 74However he has reduced his consultation hours to 3 hours in the morning and 2 hours inthe afternoon.He first started writing free blogs on medical disorders seen in the clinic in 2007 on http://kennethkee.blogspot.com.His purpose in writing these simple guides was for the health education of his patients which is also his dissertation for his Ph.D (Healthcare Administration). He then wrote an autobiography account of his journey as a medical student to family doctor on his other blog http://afamilydoctorstale.blogspot.comThis autobiography account “A Family Doctor’s Tale” was combined with his early “A Simple Guide to Medical Disorders” into a new Wordpress Blog “A Family Doctor’s Tale” on http://ken-med.com.From which many free articles from the blog was taken and put together into 1000 eBooks.He apologized for typos and spelling mistakes in his earlier books.He will endeavor to improve the writing in futures.Some people have complained that the simple guides are too simple.For their information they are made simple in order to educate the patients.The later books go into more details of medical disorders.He has published 1000 eBooks on various subjects on health, 1 autobiography of his medical journey, another on the autobiography of a Cancer survivor, 2 children stories and one how to study for his nephew and grand-daughter.The purpose of these simple guides is to educate patient on health disorders and not meant as textbooks.He does not do any night duty since 2000 ever since Dr Tan had his second stroke.His clinic is now relocated to the Buona Vista Community Centre.The 2 units of his original clinic are being demolished to make way for a new Shopping Mall.He is now doing some blogging and internet surfing (bulletin boards since the 1980's) startingwith the Apple computer and going to PC.The entire PC is upgraded by himself from XT to the present Pentium duo core.The present Intel i7 CPU is out of reach at the moment because the CPU is still expensive.He is also into DIY changing his own toilet cistern and other electric appliance.His hunger for knowledge has not abated and he is a lifelong learner.The children have all grown up and there are 2 grandchildren who are even more technically advanced than the grandfather where mobile phones are concerned.This book is taken from some of the many articles in his blog (now with 740 posts) A Family Doctor’s Tale.Dr Kee is the author of:"A Family Doctor's Tale""Life Lessons Learned From The Study And Practice Of Medicine""Case Notes From A Family Doctor"

    Read more from Kenneth Kee

    Related to Abnormal High Fever (Malignant Hyperthermia), A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions

    Related ebooks

    Medical For You

    View More
    View More

    Related podcast episodes

    Related articles

    • UNLIMITED

      Energy Medicine

      May 23, 2021

      Energy Medicine
      4 min read

    • UNLIMITED

      Beating Adrenal Fatigue

      Jan 22, 2023

      Beating Adrenal Fatigue
      4 min read

    • UNLIMITED

      Natural Treatments For SLE

      Sep 26, 2021

      Q I’ve just been diagnosed with systemic lupus erythematosus and would like to know if there’s any evidence on natural therapies being helpful for the condition. I’m aware I need to protect my skin from the sun, pace my activities, manage stress, etc

      5 min read

    • UNLIMITED

      Holistic Helpers For Bipolar Disorder

      Nov 21, 2021

      Q My daughter has bipolar disorder and takes medication for it, but still suffers badly with symptoms. Can you recommend any holistic therapies? S.K., via email A Formerly known as manic depression, bipolar disorder affects more than 1 percent of

      4 min read

    • UNLIMITED

      Beating Hot Flashes Naturally

      Mar 22, 2020

      Beating Hot Flashes Naturally
      2 min read

    • UNLIMITED

      Post-COVID Fatigue

      Feb 23, 2023

      Post-COVID Fatigue
      4 min read

    • UNLIMITED

      Post-COVID Fatigue

      Feb 23, 2023

      Post-COVID Fatigue
      4 min read

    • UNLIMITED

      Coping with AGORAPHOBIA

      Aug 10, 2022

      Coping with AGORAPHOBIA
      3 min read

    • UNLIMITED

      If You Suspect Hashimoto’s...

      Nov 24, 2019

      Georgia Lennard, nutritionist and advanced physical rehabilitation trainer at Beyond Balance in London, recommends you seek out a functional medicine clinic and get certain lab tests done, including: Antithyroid antibodies test. The antithyroid anti

      3 min read

    • UNLIMITED

      Living Well

      Apr 27, 2022

      Next time you’re feeling overwhelmed, try these quick fixes to feel more zen Walking promotes the release of endorphins, which relax us and improve our mood. It doesn’t have to be brisk – even a gentle stroll can be a noticeable stress reliever. Stu

      3 min read

    • UNLIMITED

      Doctor Gill

      Nov 8, 2023

      Two recent trials suggest daily multivitamin supplements are beneficial for cognition. Firstly, among 3,500 older adults randomly assigned to vitamin supplements or placebo, episodic memory (tested by ability to learn and recall lists of unrelated wo

      4 min read

    • UNLIMITED

      Body On Fire

      Sep 24, 2023

      Body On Fire
      8 min read

    • UNLIMITED

      Homoeopathy for Allergies & Food Intolerances

      Feb 6, 2019

      Dear Reader, Welcome to the annual homoeopathy lift-out. The theme of this issue is allergies and food sensitivities and contains many examples of how homoeopathy can assist with these common conditions. According to the Australasian Society of Clini

      3 min read

    • UNLIMITED

      Thyroid On The Blink

      Nov 13, 2020

      Thyroid On The Blink
      2 min read

    • UNLIMITED

      Fatigue Can Wreck You

      Aug 17, 2023

      Fatigue Can Wreck You
      14 min read

    • UNLIMITED

      The problem: Epilepsy

      Mar 2, 2021

      The problem: Epilepsy
      3 min read

    • UNLIMITED

      How I Beat Fibromyalgia

      Sep 22, 2019

      How I Beat Fibromyalgia
      9 min read

    • UNLIMITED

      Q&A THYROID GONE WONKY

      May 17, 2024

      Email your question for our experts to [email protected] Please note that experts unfortunately cannot respond to each question personally. The answers provided on these pages should not replace the advice of your doctor. Q I've just been diagn

      2 min read

    • UNLIMITED

      Doctor Gill

      Jul 3, 2024

      This and vestibular neuritis are types of inner ear infection that affect your balance Labyrinthitis and vestibular neuritis are problems with different parts of the inner ear, needed for balance. Labyrinthitis is inflammation of a group of fluid-fi

      4 min read

    • UNLIMITED

      Ask The Expert

      Jun 9, 2022

      Q MY GRANDSON GETS LOPERAMIDE FROM THE PHARMACY FOR DIARRHOEA. IS IT SAFE? ALoperamide is an over-the-counter drug bought to treat short-term diarrhoea such as travellers’ diarrhoea. At recommended doses, it acts on receptors in the gut to control d

      3 min read

    • UNLIMITED

      Your Health

      Sep 23, 2021

      With Dr Harriet Bradley, from the digital healthcare provider Livi (livi.co.uk) Q Whenever I eat cake or rich foods, my face feels really tingly while I’m eating, and for a few minutes after. Why is this happening? Monica, Carlisle A A tingling sensa

      3 min read

    • UNLIMITED

      Is the World Making You Sick?: The chemicals in our everyday lives are, argues immunologist Claudia Miller.

      Jul 24, 2014

      In 1962, physicist and historian Thomas Kuhn proposed that science makes progress not just through the gradual accumulation and analysis of knowledge, but also through periodic revolutions in perspective. Anomalies and incongruities that may have bee

      7 min read

    • UNLIMITED

      Stress: The Cancer Connection?

      Mar 26, 2023

      Stress: The Cancer Connection?
      9 min read

    • UNLIMITED

      Support Your ENERGY SOURCE

      Jun 12, 2020

      Support Your ENERGY SOURCE
      3 min read

    Related categories

    Reviews for Abnormal High Fever (Malignant Hyperthermia), A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions

    0 ratings

    0 ratings0 reviews

    What did you think?

    Tap to rate

    Review must be at least 10 words

      Book preview

      Abnormal High Fever (Malignant Hyperthermia), A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions - Kenneth Kee

      Abnormal High Fever

      (Malignant Hyperthermia),

      A

      Simple

      Guide

      To

      The Condition,

      Diagnosis,

      Treatment

      And

      Related Conditions

      By

      Dr Kenneth Kee

      M.B.,B.S. (Singapore)

      Ph.D (Healthcare Administration)

      Copyright Kenneth Kee 2017 Smashwords Edition

      Published by Kenneth Kee at Smashwords.com

      Dedication

      This book is dedicated

      To my wife Dorothy

      And my children

      Carolyn, Grace

      And Kelvin

      This book describes Abnormal High Fever, Diagnosis and Treatment and Related Diseases which is seen in some of my patients in my Family Clinic.

      (What The patient Need to Treat Abnormal High Fever)

      This eBook is licensed for your personal enjoyment only. This eBook may not be re-sold or given away to other people. If the patient would like to share this book with another person, please purchase an additional copy for each reader.

      If you’re reading this book and did not purchase it, or it was not purchased for your use only, then please return to Smashwords.com and purchase your own copy.

      Thank you for respecting the hard work of this author.

      Introduction

      I have been writing medical articles for my blog http://kennethkee.blogspot.com (A Simple Guide to Medical Disorder) for the benefit of my patients since 2007.

      My purpose in writing these simple guides was for the health education of my patients.

      Health Education was also my dissertation for my Ph.D (Healthcare Administration).

      I then wrote an autobiolographical account of his journey as a medical student to family doctor on his other blog http://afamilydoctorstale.blogspot.com.

      This autobiolographical account A Family Doctor’s Tale was combined with my early A Simple Guide to Medical Disorders into a new Wordpress Blog A Family Doctor’s Tale on http://kenkee481.wordpress.com.

      From which many free articles from the blog was taken and put together into 800 amazon kindle books and 200 into Smashwords.com eBooks.

      Some people have complained that the simple guides are too simple.

      For their information they are made simple in order to educate the patients.

      The later books go into more details of medical disorders.

      The first chapter is always from my earlier blogs which unfortunately tends to have typos and spelling mistakes.

      Since 2013, I have tried to improve my spelling and writing.

      As I tried to bring the patient the latest information about a disorder or illness by reading the latest journals both online and offline, I find that I am learning more and improving on my own medical knowledge in diagnosis and treatment for my patients.

      Just by writing all these simple guides I find that I have learned a lot from your reviews (good or bad), criticism and advice.

      I am sorry for the repetitions in these simple guides as the second chapters onwards have new information as compared to my first chapter taken from my blog.

      I also find repetition definitely help me and maybe some readers to remember the facts in the books more easily.

      I apologize if these repetitions are irritating to some readers.

      Chapter 1

      Abnormal High Fever (Malignant Hyperthermia)

      What is Abnormal High Fever (Malignant hyperthermia)?

      Malignant hyperthermia (or abnormal high fever) is an genetic disorder that produces a rapid increase in body temperature (fever) and severe muscle contractions (myalgia) when the affected person is provides

      Enjoying the preview?
      Page 1 of 1