Paul Colbon

At Avanti Research™, we understand that high purity and reproducibility are essential for advancing scientific knowledge. Our fully synthetic glycosphingolipids meet the rigorous standards that research and pharmaceutical development demand. By choosing Avanti’s synthetic glycosphingolipids, researchers gain access to consistent, high-quality products that support a broad range of investigations, from cellular signaling to therapeutic development. We’re committed to empowering your research and facilitating breakthroughs in understanding complex biological processes with synthetic lipids engineered for accuracy and reliability. Click here to Discover the difference > https://ow.ly/XNbP50U6kW7

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Do you need some R&D for a small molecule? We are proud of our leading custom complex chemical synthesis services from experts in our labs in the UK and Europe. From complex intermediates, novel NCEs and improved processes for your existing molecules, including identifying biocatalytic routes for all or part of the process. Then if you need it, we can take your project onwards for large-scale or GMP production at one of our high quality manufacturing sites. Oligosaccharide synthesis - Nucleosides, dinucleotides and analogues Heterocyclic chemistry - Fluorination, phosphorylation and sulphation chemistry - Novel enzyme substrates - Natural product synthesis - Impurities and metabolites - Protein conjugation, biotin and click linkers - Biocatalysis - Bioconjugation See more at https://lnkd.in/epdWSjtz #chemicalindustry #complexchemicals #biosynth

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Peptide modifications such as cyclisation result in an increased rigidity of the peptide backbone and can be a useful strategy when wanting to mimic a specific region of a protein. Here at Alta Bioscience Ltd, we have extensive experience of synthesising structurally constrained peptides including head to tail cyclic peptides, disulfide bridged peptides and stapled peptides. To find out more about our peptide synthesis services, please visit: https://lnkd.in/ez8xJ8Ew or contact our experts at [email protected]. #peptides #peptidesynthesis #cyclicpeptide #peptidemodification

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In the latest issue of Drug Development & Delivery , Dr Suzanne Saffie-Siebert and her team review the current shortcomings and accompanying manufacturing challenges of lipid nanoparticles, and they show how these shortcomings can be addressed by SiSaf’s silicon-stabilized hybrid LNPs (#sshLNPs). ⬇️Read the article https://lnkd.in/dGXT22va 🔗 Learn more about SiSaf and our Bio-Courier technology: sisaf.com #RNA #LNP #sshLNP #BioCourier

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Our latest whitepaper explores lab automation solutions available to CROs and CDMOs ✅ This includes the benefits they can bring and how true infrastructure-level automation can revolutionise the lab experience for everyone - from scientists to clients to patients. Download the ungated content here, no catch ➡️ bit.ly/44tSgwb #CROs #LabAutomation #Whitepaper

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🙌…and therapy developers push even harder to implement our revolutionary Celledonia™️ cell analyser at scale. 🏴󠁧󠁢󠁳󠁣󠁴󠁿An homage to Caledonia squared to the power of Celidonius (“a man born blind whom Jesus healed in the Gospel of John 9:1–38”): AuraCyt empowers our industry to finally “See the Unseen”… 1️⃣ predicting the unpredictable: high-producing clones in Cell Line Development - saving 3-6 crucial months in that process, every single time; 🧫 2️⃣ enabling scale-out of CGT to manufacture the unmanufacturable; 🧬 3️⃣ unlocking automation with rapid cell analysis for direct CGT process control;⏰ https://lnkd.in/e_bPw6Wz https://lnkd.in/eUE2Fhdw #CellAnalysis game-changer 👾| #CellAndGene | #CGT 🧬| #AdvancedTherapies 🧪 #SpeedToMarket 🏁 | #SpeedToPatient 👩‍🔬⌛️👨‍🔬

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With complex structure, bioconjugates often come with challenges across entire development journey. WuXi XDC offers an unprecedented single-source approach for ADC/bioconjugate discovery, development and manufacturing, covering antibody intermediates and other biologics intermediates, chemical payloads and linkers, as well as bioconjugate drug substances and drug products. This comprehensive one-stop approach provides more efficiency, flexibility, lowered risks, fewer transactional costs, and industry-leading 13 to 15-months DNA to IND timelines. Partner with WuXi XDC, advance your bioconjugate journey to commercial success. Let's get started! ​ https://www.wuxixdc.com   #conjugate #conjugates #bioconjugation #bioconjugate #bioconjugates #adc #adcs #antibodydrugconjugate #antibodydrugconjugates #cmc #cdmo #crdmo #biomanufacturing #bioprocessing

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🔬 Discover DuetMab Technology with evitria DuetMab is a cutting-edge bispecific antibody format designed to address the challenges of antibody engineering with a very specific approach. How DuetMab Works: DuetMab technology achieves correct heavy-light chain pairing by replacing the native disulfide bond in one of the CH1-CL interfaces with an engineered disulfide bond at a different location. This method significantly reduces the risk of mispairing, a common issue in bispecific antibody production, and ensures stable and effective antibody assembly. At evitria, we are specialized in producing various bispecific antibody formats, including DuetMab. But not only do we express them; we can also support our customers in choosing the ideal bsAb format for their project. Have you already made your own experiences with this format? Let us know in the comments! #DuetMab #BispecificAntibodies #Biotechnology #MedicalInnovation #AntibodyEngineering #evitria

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Having trouble figuring out how to register your stall for Pharma Festives 3.0? 🤨 Don’t stress, here’s a simple guide to help you reserve your stall.

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Active Pharmaceutical Ingredients Cdmo Market Size, Share & Trends Analysis Report By Synthesis (Synthetic, Biotech), By Drug (Innovative, Generics), By Application (Oncology, Hormonal, Glaucoma, Cardiovascular, Diabetes, Others), By Workflow (Clinical, Commercial), Global Economy Insights, Regional Outlook, Growth Potential, Price Trends, Competitive Market Share & Forecast, 2023 - 2031 IMIR Market Research Pvt. Ltd. The quality of APIs has a noteworthy effect on the efficacy and safety of medications. Hence, selecting a CDMO that can provide the precise API at the required strength, purity, and quality is a vital decision for drug development companies. 📚 𝐆𝐞𝐭 𝐭𝐡𝐢𝐬 𝐑𝐞𝐩𝐨𝐫𝐭 𝐚𝐭 𝐃𝐢𝐬𝐜𝐨𝐮𝐧𝐭𝐞𝐝 𝐏𝐫𝐢𝐜𝐞 👇 https://lnkd.in/dypUzFhK 📚 𝐓𝐨𝐩 𝐌𝐨𝐫𝐞 𝐊𝐞𝐲 𝐏𝐥𝐚𝐲𝐞𝐫𝐬 𝐀𝐫𝐞👇 5N Plus Inc. A.R. Life Sciences Pvt Ltd. Hyderabad,. AbbVie. abcr GmbH AGC Pharma Chemicals AmbioPharm - A Global Peptide CDMO Axplora Biocon Boehringer Ingelheim Bristol-Myers Squibb Pharma Company C.H. Boehringer Sohn AG & Co. KG Cambrex ChemCon GmbH Curia Global Dipharma Francis S.r.l Dr. Reddy's Laboratories. EUROAPI HAS Healthcare Advanced Synthesis SA Hikal Ltd IBI - Istituto Biochimico Italiano Giovanni Lorenzini S.p.a. Indena IOL Chemicals and Pharmaceuticals Limited Lonza Lupin MINAFIN GROUP MINAKEM Moehs Iberica Mylan. Neuland Laboratories Limited Novasep Olon Ricerca Bioscience Piramal Group PMC Group International, Inc. PMC Group. Polpharma PolyPeptide Group Recipharm Samsung Biologics Saneca Pharmaceuticals a.s. #lnp #cdmo #drugmanufacturing #pharmaceuticals #pharmaceutical #fda #mrna #therapeutics #drugdelivery #polymernanoparticle #nanoparticle #lipid #university #therapeutic #vaccines #vaccine #dna #rna #mrnavaccines #commercial #pharmaceuticalmanufacturing #sterile #formulation #preclinical #clinical #toxicology #sterileprocessing #fillandfinish #fillfinish #drugdevelopment

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𝗣𝗩𝗔-𝗯𝗮𝘀𝗲𝗱 𝗳𝗼𝗿𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻𝘀 𝗮𝘀 𝗮 𝗱𝗲𝘀𝗶𝗴𝗻-𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 𝗽𝗹𝗮𝘁𝗳𝗼𝗿𝗺 𝗳𝗼𝗿 𝗼𝗿𝗮𝗹𝗹𝘆 𝗱𝗶𝘀𝗶𝗻𝘁𝗲𝗴𝗿𝗮𝘁𝗶𝗻𝗴 𝗳𝗶𝗹𝗺 𝗺𝗮𝘁𝗿𝗶𝗰𝗲𝘀 A multitude of pharmaceutical formulations with varying mechanical and biopharmaceutical properties have emerged from the modification of the original polymeric bulk. Here the scientists propose different formulation approaches, i.e. solvent casting (SC), 3D printing (3DP), electrospinning (ES), and lyophilization (LP) that enabled us to adjust the disintegration time and the release profile of poorly water soluble haloperidol (HAL, BCS class II) from PVA (polyvinyl alcohol) based polymer films while maintaining similar hydrogel composition. In this study, the solubility of haloperidol in aqueous solution was improved by the addition of lactic acid. #PVA #3Dprinting #electrospinning

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#STORM's Vice President Medicinal Chemistry, Beth Thomas, is presenting at the Society for Medicines Research's 'Modulating RNA with oligonucleotides or small molecules' conference today!   Beth will be presenting from 13.50 - 14.30 BST on the 'Discovery of STC15, the First Molecule Specifically Targeting an RNA Methyltransferase Enzyme to Enter Clinical Development'.   The one-day conference brings together speakers who will explore successful approaches, future opportunities, and novel approaches being explored in industry and academia to exploit ways to downregulate, upregulate or change splicing in protein synthesis for therapeutic purposes.   #lifesciences #biotech #drugdiscovery #research #STC15 #METTL3 #METTL1 #RNA #modification

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BioGlyph and Dotmatics building the Next-Generation of workflows for Multispecific Antibodies

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Are you engaged in early-stage therapeutic antibody production? Tired of searching everywhere for clear guidance on the key steps at each production phase? We’ve created a handy infographic that outlines every stage on the path to an antibody drug—from design, expression, purification and beyond—helping you advance your molecule to CMC. Today, we’re sharing the first step: molecular design. Stay tuned for the next phase—expression—coming next month! Do you find infographics like this useful? Share your feedback via our quick survey! ▶️https://lnkd.in/ejEZiby9 #antibodytherapeutic #drugdiscovery #WuXiBiologics #antibodyproduction #ProteinProduction

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Read our latest blog for a succinct overview of LC-MS analysis of targeted protein degraders and their metabolites 👉 https://bit.ly/4f0pQyl #SCIEXPharma #SCIEXforScience #MassSpec #MassSpectrometry

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Want to master navigating the complexities of peptide synthesis in CMC? The journey from peptide concept to clinical-grade product is paved with unique and specific CMC (Chemistry, Manufacturing, and Control) challenges. The complexity and specific attributes of peptides require tailored approaches at every stage of development. We’ve highlighted some of the primary hurdles in peptide synthesis below and explain how 3Biotech is well-equipped to guide you through each one. Take a look through the slides below. At 3Biotech, our mission is to de-risk and accelerate every stage of peptide CMC development, from lead optimization to GMP manufacturing. With our expertise, you gain a partner who understands the intricacies of peptide synthesis and is dedicated to delivering solutions that meet the highest industry standards. You can find out more about how we can work together to transform peptide challenges into milestones on the path to clinical success by clicking on the link below. 👇 https://lnkd.in/e2t_CHdw #Biotech #CMC #Drugdevelopment

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*Molecules of the Month - July Edition* This month, our MotM focuses on Target Protein Degradation and some of the medicinal chemistry approaches that are applied within this area of drug discovery. Read on to find out how LCC's proprietary linkers, virtual libraries and parallel synthesis capabilities can help accelerate you drug discovery efforts. 👇 #TargetProteinDegradation #Linkers #VirtualLibraries #DrugDiscovery

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