Cedric Hurth

Nanalysis Benchtop NMR spectrometers are proving an asset to both science and society - https://lnkd.in/ek59y924 This study, in partnership with King's College London and using Nanalysis benchtop spectrometers, highlights the potency of qNMR analysis as a cornerstone of harm reduction strategies to protect our young adults from illicit drugs such as MDMA. #nmr #qnmr #benchtopnmr

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Thanks Roy Goodacre, and team for sharing this great new paper on the comparison of bulk FTIR and single bacterial cell O-PTIR for bacterial classification, even down to the strain level! Quote from the abstract: " When combined with chemometric analysis, we showed that O-PTIR is capable of discriminating different between genera, species and strains within species to a degree comparable with FTIR. Furthermore, small variations in the amide bands associated with differences in the protein structure can still be seen in spite of smaller sample sizes. This demonstrates the potential of O-PTIR for single-cell bacterial analysis and classification." #optir #FTIR #Raman #bacteria https://lnkd.in/gyh-mbvX

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Computational #NMR is a branch of science that uses computer simulation to study the magnetic properties and interactions of chemical and biological systems. Watch this interview with Prof @Ilya Kuprov (University of Southampton), a magnetic resonance #spectroscopy & imaging specialist focusing on large-scale computer simulations of magnetic processes in chemical and biological systems and has recently published a major monograph on spin physics: https://lnkd.in/dBE8KtDJ Learn more: https://lnkd.in/d4rpGAX3 #ComputationalNMR #MakeMRmoreRelevant

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Issue 39 is here 🎉 Our front cover this week features Mahesh Hariharan, Brijith Thomas et al 🤩 'Electron diffraction and solid-state NMR reveal the structure and exciton coupling in a eumelanin precursor' 🔗 https://lnkd.in/e7GyvdVM #ChemSciCovers

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In our latest featured #DigitalDiscovery article, Haas, Hardy, Sowndarya, Adams, Coley, Paton and Sigman demonstrate that descriptors for organic compounds can be predicted on-the-fly at a high degree of accuracy by using DFT-level libraries as training data for a GNN. Read the open access paper for more: https://lnkd.in/dPirddWr

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As I am being nostalgic today. I learn't biological electron microscopy at Aberystwyth University and this served me well for many years when I was in the lab studying cell adhesion. This image of a cell adhering to a plastic surface at 5 minutes after seeding is one of my best SEM works. I do not say image because it is much more from a light perfect fixation, careful dehydration and thin metallic coating to imaging with a technique I developed in the 90's Low Voltage Backscattered Electron Imaging to show how a cell really looks (as many images were and still are white blobs of charging). The papers are old, the preparation is time consuming, the operation of the filed emission scanning electron microscope had to be at highest degree but the result- it speaks for itself. Unfortunately I have never seen more images like this, which means I failed to pass this on well to enough youngsters. In the words of Monty Python "I am not dead yet" so maybe this can inspire some to look into this and create beautiful important scientific images of what happens within minutes of cell adhesion to implants. most of the papers are not in Pubmed, one of the newer ones is Advantages of stereo imaging of metallic surfaces with low voltage backscattered electrons in a field emission scanning electron microscope. Richards RG, Wieland M, Textor M. J Microsc. 2000 Aug;199 (Pt 2):115-23. doi: 10.1046/j.1365-2818.2000.00717.x. PMID: 10947904 maybe this pops up in my talk at Aberystwyth University Careers Service in November- so much to choose from

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Interested in hyperpolarisation in NMR? Read our latest blog from Billy Hale, where he discusses how it has been recently used on X-Pulse by visiting researchers from the Duckett Group The University of York. Click the link below to read the full blog post: https://okt.to/lN7uYr #NMRSpectroscopy #Spectroscopy #MagneticResonance #XPulse

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🚀 Introducing Python for Electrochemistry Research 🚀 Join ECS - The Electrochemical Society for a live webinar to discover the advantages of using Python in your electrochemical research. Date: 28 August 2024 at 3 p.m. BST / 10 a.m. EDT 🔍 This session is perfect for electrochemists new to programming. We’ll cover: Basic programming concepts Data handling, treatment, fitting, and visualization Electrochemical simulation Resources for learning Python An interactive Q&A session will follow the presentation. Register today! 👉 https://ow.ly/t5HA50SSVsL #Electrochemistry #Python #Research #Webinar #DataScience #ECS #Programming #Physics

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Sutliff, Martin et al. show how appropriately designed machine learning approaches can allow NIR-based sorting of different polyolefins in our latest featured #DigitalDiscovery article. Their study provides guidance on appropriate methods for correction, filtering, scaling and classification of spectroscopic data. Find out more in the #openaccess paper: https://lnkd.in/e_wg4wYK

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Here De put at al demostrates the power of cyclic ion mobility spectrometry (cIMS) for the in-depth characterization of oligosaccharides and the seperation of anomeric species 🎯 Summary: De put at al used the monosaccharide mobilograms as references. De put at al was able to determine the composition and anomeric configuration of 4β-galactobiose by studying the monosaccharide fragments generated by collision-induced dissociation Quoting De put at al "We were able to separate galactose and glucose anomers by exploiting the high ion mobility resolution of cIMS." Also De put at al do state that disaccharides used in this study only consist of galactose and glucose #science #massspectrometry #massspec #chemistry #oligosaccharides #lcms #biotech #biopharmaceutical #ionmobility #research #glycans https://lnkd.in/eH9zzJFw

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💎Protein crystallization and structure determination at room temperature in the CrystalChip ➡️ https://buff.ly/49dUqSP #Crystallography #CrystalChip #SerialCrystallography #StructuralBiology #ProteinBiology #ProteinCrystals

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Breakthrough in ocular device technology could revolutionise treatment for #cataracts The University of East Anglia (UEA) has developed a novel resin for #3Dprinting #intraocular devices which could enhance the manufacture of eye implants used in cataract & refractive surgeries. https://bit.ly/3SgNrkX via The Engineer UK An artificial intraocular lens (IOL) is primarily required for people with cataracts, a condition where the eye’s natural lens becomes cloudy, obscuring vision. They can also be also used to correct refractive errors such as #myopia (near-sightedness), #hyperopia (far-sightedness) and #presbyopia (when eyes gradually lose the ability to see things clearly up close, as a normal part of aging). “For the first time, we have developed a resin that can be used to print ocular devices directly,” said lead author Dr Aram Saeed (Aram S.), Associate Professor in Healthcare Technologies at UEA's School of Pharmacy. “While still in the early stages, the ability to 3D print these lenses could significantly enhance eye care for patients by offering unprecedented levels of customisation and design precision, potentially leading to better clinical outcomes.” Historically, #IOLs have been made from a variety of materials, including glass and silicone, although more recently the industry has significantly evolved to predominantly use acrylic materials. Currently, hydrophilic and hydrophobic #acrylic are most used due to their #optical clarity, flexibility, #biocompatibility and for their stability and safety within the eye. Current methods of making IOLs use lathing & moulding techniques. The researchers said that while these methods offer the production of well-engineered & high-optical quality devices, they also come with limitations, particularly in terms of design complexity & customisation. This UEA innovation could enhance the production of ocular devices by creating tailored #lenses for each patient’s eye shape & vision needs, provide faster production, and allow for complex designs. The research team also said that by using their 3D printing technology, the production cost of custom lenses could decrease, and that new materials could be tested and utilised. The study found that the #3Dprinted lenses had good optical clarity, could be folded, and implanted into a human capsular bag. “Our proof-of-concept paper is the first in a series that will [...] set the stage for transforming eye care practices globally,” said Dr Aram Saeed. The researchers have begun work to ensure the process works accurately on a larger scale and to increase the printing resolution to improve dimensional accuracy. They said that #ClinicalTrials could start in the next few years. The UEA team was awarded a United States #patent, and received funding from UEA’s Innovation Development Fund and Proof-Of-Concept grants, The Humane Research Trust, the EPSRC, UEA’s Impact Acceleration Account and the Medical Research Council (MRC).

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"The availability for purpose-built commercial lab space in the UK remains limited and therefore constrains market movement. Still in 2024, supply will somewhat improve as we begin to see new lab space delivered. We estimate around 2 million sq ft of lab space will be completed in 2024, mostly in the Golden Triangle of Cambridge, London, and Oxford... Beyond the South East, Manchester💡continues to develop its leading Life Sciences position in the North, contributing 27% of this year's total UK uptake (200,000 sq ft)." UK Real Estate Market Outlook 2024 (Life Sciences): https://lnkd.in/e_cWNhSY

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From Jove - Learn about the protocol for the crystallization of proteins at the Research Complex at Harwell & subsequent in situ X-ray crystallographic data collection from crystals within the plates at one of Diamonds beamline - https://zurl.co/VAp3 #crystallography

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Journal paper publication: We ara happy to announce that our academic article on THz phenomena has been published in Jounrnal of Applied Physics w/ an open access opition under the S2O program by AIP (download free) "Generation of a coherent longitudinal optical phonon plasmon coupled mode in an n-type InSb single crystal in the absence and/or strong suppression of the photo-Dember effect confirmed with the use of terahertz time-domain spectroscopy". Journal of Applied Physics vol. 136, issue 16, article no. 163103 1-7 (2024). Hideo Takeuchi and Takahiro Sumioka. Key word: Proposal for the coherent LO phonon generation in the absence of the photo-Dember effect in narrow-gap semiconductors, Impulisive stimulated Raman scattering, THz time-domain spectroscopy in the emssion detecttion configration

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