Adam Inche

This latest episode was inspired by the upcoming biosecurity regulations in the USA. I did some research on the topic to provide information regarding China, USA, UK and the EU. I hope you will find it interesting. #clinicalresearch #genomicdata #biosecurity

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Finally, the BIOSECURE Act has been passed to preclude some Chinese key players, including WuXi AppTec, WuXi Biologics, BGI Group, MGI and Complete Genomics, from the supply chain in biotech development and manufacturing services, which the U.S. drugmakers heavily rely on to grow their businesses. The geopolitics has been the major factor in shaping the strategic landscape between the U.S. and China during these years, and now it even impacts on the biopharmaceutical industry. My question is: how can Taiwanese companies grasp this opportunity to play a good game?

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https://lnkd.in/eWsz7CcU With over 60 references, The Neospora Antibody Test Kit from VMRD, Inc. and available from 2BScientific Ltd. employs a competitive ELISA technique to detect the presence of Neospora caninum antibodies in serum samples from cattle. 🐝 Exceptional Precision: Evidenced through sensitivity and specificity assessments, ensuring dependable identification of both positive and negative sera. 🐝 Distinct Discrimination: 5% of sera registered within ±5% of the cut-off value, underscoring exact differentiation between positive and negative samples. 🐝 Streamlined Screening: Streamlines the examination of extensive sample sets, as evidenced by the analysis of 4,323 sera with unknown serologic statuses. 🐝 Robust Confidence: Minimal overlap near the cut-off value inspires assurance in the kit's accuracy. For your own research reagents, get in contact at [email protected] with any queries about this ELISA, our products, or anything concerning life science! #petwelfare #neospora #hereforyou

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It is interesting and concerning to see the reaction and use of $$$ by Chinese companies in the form of lobbying to influence the safety of our drug supply. There has been a big push for on-shore drug manufacturing, but given the global nature of the supply chain for drug manufacturing, that ship has long sailed. But, I believe that we can't be naive about the geopolitical environment that we find ourselves in. At this point, we must ensure that we have a robust supply chain at least from nations that cannot retaliate and disrupt the supply of needed medications! Our politicians should consider how vulnerable we currently are, which I think was the genesis of the BIOSECURE Act. https://lnkd.in/g_GJhcte

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So, who exactly is Avacta, and why should you care? Well, #AVCT is a British biotech company that’s spearheading innovations in cancer treatment. They’ve got two main divisions: Therapeutics, where they’re developing next-generation cancer drugs, and Diagnostics, which helps healthcare professionals with advanced testing tools. But it’s really their Therapeutics Division that’s turning heads, especially with their novel cancer treatment approach, aiming to target tumours more precisely than ever before. https://lnkd.in/ecvZ-mwX

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🙌…and therapy developers push even harder to implement our revolutionary Celledonia™️ cell analyser at scale. 🏴󠁧󠁢󠁳󠁣󠁴󠁿An homage to Caledonia squared to the power of Celidonius (“a man born blind whom Jesus healed in the Gospel of John 9:1–38”): AuraCyt empowers our industry to finally “See the Unseen”… 1️⃣ predicting the unpredictable: high-producing clones in Cell Line Development - saving 3-6 crucial months in that process, every single time; 🧫 2️⃣ enabling scale-out of CGT to manufacture the unmanufacturable; 🧬 3️⃣ unlocking automation with rapid cell analysis for direct CGT process control;⏰ https://lnkd.in/e_bPw6Wz https://lnkd.in/eUE2Fhdw #CellAnalysis game-changer 👾| #CellAndGene | #CGT 🧬| #AdvancedTherapies 🧪 #SpeedToMarket 🏁 | #SpeedToPatient 👩‍🔬⌛️👨‍🔬

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https://lnkd.in/e83BGiDZ Immune Checkpoint Proteins available at 2BScientific Ltd. from our trusted supplier Bio X Cell Immune checkpoint proteins are regulators of the immune system that prevent foreign antigens and preferably the host’s immune cells from attacking, thereby regulating self-tolerance, immune homeostasis and prevent autoimmunity. The checkpoint proteins can send two types of signals to express these immune responses: 🐝 Co-stimulatory checkpoints deliver positive signals to T cells following their binding to ligands and receptors on antigen-presenting cells (APCs). They can stimulate immune responses, including CD27, CD40, OX40, GITR, 4-1BB, CD28, ICOS and many more. 🐝 Co-inhibitory checkpoints deliver negative signals to T cells upon interaction with their counterparts on the APCs. They can inhibit immune responses, including PD1, PD-L1, CTLA-4, VISTA, CD155/TIGIT, TIM-3, and more. #2BScientific #herefor you #bioxcell #immunecheckpointproteins

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STEM Learning UK STEM Ambassadors Paper chromatography is one of the small number of practical lessons taught at most schools - but the results are usually pretty poor ! Even video guides show poor separation & lots of streaking/merged colours which makes Rf measurement impossible. So I thought I'd have a go & investigate at different conditions using standard resources to separate a black dye - see photo. Nice separation, reproducible & easy to draw around colour spots to measure Rf. Have you tried different conditions to give good quality paper chrom? If so, upload photo & share.

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Rapid, detailed cell analysis technology soon ready to assess the difference it can make to process insights and timelines

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A few thoughts to share! Sometimes I don't shout loud enough, so please spare me a few minutes for this message 🙂 I know you have a choice of testing labs. XCellR8 is the leading UK-based, GLP in vitro testing lab for the cosmetics and chemical industries. But we're more than a testing lab! Our passion and commitment to replace animal testing with human relevant science, for both scientific and ethical reasons, drives everything that we do. We're not paying lip service to the topic, it's at the very core of who we are. We started 16 years ago when the landscape for "alternatives" (now an outdated word!) was very, very different. In vitro testing wasn't mainstream and our commitment to a completely animal product free approach was considered radical and "unrealistic". We've been trailblazers and are so excited to see the increase in support for this topic in recent years. Just as in any area of life, where you choose to spend your budget for testing can make a huge difference. Please support us as we look to expand our work, and keep up the trailblazing one day at a time, until animal testing is consigned to history in favour of new approach methodologies! Please feel free to share our message with relevant colleagues and contacts 🙏 #xcellr8 #xcellr8labs #redefiningtesting #animalfreetesting #producttesting #safetytesting #cosmeticstesting #crueltyfree #vegan

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An interesting article this week, which I think is linked to the paper I mentioned last week about justifying specifications. One of the debates we often had when writing new submission documentation was around the number of significant figures or decimal places to report results to. As the paper points out you should always have an understanding of the limitations of the analytical methods you are using to generate your data and the inherently limited precision of many biological experiments. https://lnkd.in/evwRNdWk

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Biologics are taking the UK by storm, with prescriptions increasing by 62% over the last 5 years. Surely drug spending saw a similar sort of increase? Not! Increased access to these life changing therapies was achieved without cost increases for the system overall due to the significant savings they can produce compared to the originator and other competing products. Free, fair and open competition is the key. Double taxation with mandatory clawbacks like VPAG threatens the future sustainability of biosimilars. 🔗 https://lnkd.in/gXFw6MB7 #Biosimilars #Biologics #HealthcareExpenditure #DrugSpending

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NICE already recommended Genedrive as the point-of-care test of choice in its draft guidance before clopidogrel administration in the management of Ischemic Stroke (IS) and Transient Ischaemic Attack (TIA) patients. Really great achievement outperforming the laboratory test with respect to accuracy! #diagnostics #pharmacogenetics #PGx #pointofcare #POCT #stroke #nhs

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Stemcell Scientists….. frustrated with lack of functional data for QC released products ? MICROGLIA SENSORY Neurons MOTOR Neurons Take a look at this excerpt from our fQC webinar where our senior scientist David Wallbank demonstrates potential functional QC assays that could be used for three of our main cell types: microglia, sensory neurons and motor neurons. We think fQC could form the next step in the quality chain, alongside our ISO 9001-accredited QMS, standard QC panel and in-house expertise. If you agree that quality is central to the success of advanced in vitro models, make sure to watch the full webinar: "QC, Functional QC & iPSCs: the importance in better human disease modeling" to learn more. Access the webinar here: https://hubs.la/Q02FytlF0 If you'd like to know more about fQC, we've developed a discussion document which you can download here: https://hubs.la/Q02FyrzH0 #cellculture #organoids #research #drugdiscovery #drugdevelopment #microfluidics #MEA #neuroscience #motorneurondisease #alsresearch #painresearch #alzheimersresearch #biopharma #axion

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I have been asked a number of times "What does the Catapult do?" ... ✅ Medicines Discovery Catapult makes every move count. 🔬 At the frontier of drug discovery, we work with entrepreneurial scientists across the UK. We help validate their ideas, de-risk investments, and feed insights back into the sector to drive productivity and impact. 🧪 High-risk science is hard, which is why our exceptional people, equipped with the best technology, turn visions of drug discovery into commercial breakthroughs. We identify the fastest, safest route to accelerate commercial success. 🤝 Where there is unmet patient need, our National Programmes stimulate innovation through partnership. We are a national Life Sciences service. Our interventions work. Since we started, we have helped over 300 companies raise over £1bn of R&D investment. Our approach to drug discovery drives game-changing breakthroughs and improves patients’ lives! #drugdiscovery #cellularsciences #biomarkers #translationalimaging

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Are you a #biotech or #healthinnovation company looking to #raisefunds? Can you be in #London on 4th December 2024?? Are you interested in meeting a mixture of US and European Investors??? If you answer yes, please read on! RESI London 2024 is the most cost-effective opportunity you will get to attend such a high-quality, high-engagement and high-value event full of investors. What's more, it's in the UK, so for many of our #AgileLeaders network, not too far to travel! The folks at Life Science Nation are world-renowned for their #RESI investment conferences. This #RESILondon investor conference is in collaboration with One Nucleus's Genesis conference. The RESI London event merges with the #GenesisLondon 2024 at 4.30 pm on the 4 December for further networking. The venues are less than 5 minutes walk away from each other at the King's Fund on Cavendish Square and the Royal Medical Society at 1 Wimpole Street respectively. This event activity is terrific for #lifesciences in the #UK and we expect it to boost #earlystage investment for the #UK community. What's more, by using the code AgileLeaders15 you get 15% off these already great attendance rates!!! Qualified Investors go for free, so go to the RESI website to register for free if you're a qualified investor - no investment consultants or non-qualified non-professional investors need to apply. Stringent vetting is applied to all free investor applications. What RESI do exceptionally well is have qualified information on all their #investors attending so you can tell on the partnering system if they are potentially the right investor for you, or not. Typically these #RESI events have a 50:50 ratio of investors to #innovationcompanies, and this London event will be no exception. If you are a #drug, #device, #diagnostic or #digitalhealth #innovation company looking for #funding, this is a “must attend” event.  To register visit the RESI London website now to get this great 15% off deal using the AgileLeaders15 discount code. You won't get a better deal anywhere else. Space is limited, so I suggest you book your ticket ASAP to avoid any disappointment: https://lnkd.in/eSEnayPD Sponsorship Opportunities: If you are a service company, law firm or consultancy firm wanting to mix and be visible with these emerging innovation company CXOs and investors, there are some brilliant sponsorship options too, so get in touch if you are interested. For example there is an exhibitor and logo sponsorship package available for only £1,500 with two delegates, which I hope you agree is terrific value.

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Great news for the lifesciences ecosystem and life science companies seeking investment. https://lnkd.in/eW_pzWta. #startups #lifescience #biotech #pharmaceutical #innovation #drugdevelopment #investment #outsourcingpharma #BIO2024 #biotechnology #venturecapital #privateequity #investors #clinicaldevelopment #clinicalresearch

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Dr Jen Vanderhoven is bar far one of the most passionate and driven people I know. I honestly believe she is single handedly making the most Impact for #ukbiotech and #bio-based materials. Making the BBIA the fastest growing most modern trade association trying to make a #realdifference. If you want to be apart of the #bioeconomy and #biorevolution get in touch. Keir Starmer

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