Newcells Biotech Ltd

Assess Cilia Beat Frequency (CBF) in lung small airway epithelium cells (SAEC) 🫁 Cilia Beat Frequency (CBF) analysis helps assess cilia function for mucociliary clearance, evaluate drug efficacy, dosing, sustained effect and safety in the lung's small airway epithelium 🫁 Unlock a comprehensive, high-sensitivity set of data that accurately measures the effect of your compound, including fast acting ones, on mucociliary clearance. ✔️Compound evaluation for effect on ciliated cells ✔️Comprehensive, high-sensitivity cilia beating readouts for confident decision-making ✔️Mimicking of respiratory conditions for predictivity of cilia function in vivo Hear more from Megan Jo Webster, PhD, Head of Lung Platform, in the video below👇 Read more about CBF here: https://lnkd.in/e9CEZRUC #Newcells #LungAssay #Cilia #SAEC

Our latest webinar is available on-demand now! ⏯ https://lnkd.in/epmWSWWt In case you missed it, we explored standardisation, trends and innovations in respiratory in-vitro models to best devise a NAM strategy to progress your respiratory compound through the pipeline💡 Megan Jo Webster, PhD, Head of Lung Platform at Newcells and Clive Roper BSc PhD CBiol CSci ERT FRSB (Roper Toxicology Consulting Limited ) shared presentations before we opened up the floor to audience questions and general discussion 💭 Huge thanks to Clive and Megan for joining us! #Newcells #Webinar #IND #Toxicology #InVivo #InVitro

🧠 There is enormous potential for AI to transform drug discovery⚡️ From data sets and models to design and optimization, AI can play an important role if implemented correctly. We spoke to leading experts at Newcells to get their thoughts on the impact of AI for the industry. Listen to the interviews here 👉 https://lnkd.in/ensdYzks #Newcells #AI #DrugDiscovery #BioTech

#DidYouKnow Kidney is one of the most frequent targets for drug-induced toxicity, with 2% attrition in pre-clinical stages and 19% attrition in phase 3 studies. Early detection is key to reducing both costs and timelines. How valuable are #invitro vs #invivo models alone? Do they need to be combined for success and a lower rate of attrition? 🤔 Learn more here 👉 https://lnkd.in/esk-H_sc #Newcells #Nephrology #KidneyModels #KidneyTissues

👁 In vitro retinal disease modelling for retinal therapy 👁 iPSC technology allows the engineering of patient-specific retinal organoids and RPE, offering the chance to investigate disease mechanisms and evaluate efficacy of novel therapeutics in a personalised way. With models derived from human iPSCs, patient-specific gene-edited lines can be engineered allowing direct comparison between WT and mutants. Retinal disease modelling from human origin allows us to generate robust and predictive data for transitional and clinical studies. Learn more about our retinal disease models 👉 https://lnkd.in/ejQkFTq7 #Newcells #RetinalDisease #Therapeutics #iPSC

📑 Our recent study assessed the dynamics, efficiency and batch-to-batch reproducibility of Photoreceptor outer segments (POS) development across three batches of wildtype human iPSC-derived retinal organoids produced at large scale. Discover how POS play a crucial role in the process of vision and how invaluable our Retinal organoids (ROs) are in the study of retinal disease mechanisms and within drug discovery 🔬 Download the poster here 👉 https://lnkd.in/e8UBwXpe #Newcells #RetinalOrganoids #Photoreceptors #RetinaDisease

AI offers huge potential for drug discovery 🧠⚡️ Companies across the ecosystem, from large pharmaceuticals to biotech firms, are already investing in AI 💸 At Newcells we have invested in a new imaging platform which uses high-end AI technology, and we are looking at ways to improve the automation of our data analysis. We spoke to Dr Mike Nicholds, CEO at Newcells, to find out how AI is accelerating drug discovery for our clients. Read or listen to the full interview here 👉 https://lnkd.in/ensdYzks #Newcells #AI #DrugDiscovery #Imaging

⚠️ Inhalation of toxic microparticles can damage lower airway epithelial cells ⚠️ Sustained microinjury of the epithelium results in aberrant epithelial-fibroblast communication via the release of fibrotic stimuli, including TGF-β1. Get up to speed with the utilisation of high-content imaging for the study of lung fibrosis 👉 https://lnkd.in/ecX4vMsA #Newcells #EpithelialCells #LungFibrosis

There is enormous potential for AI to transform drug discovery 🧠🧪 From data sets and models to design and optimization, AI can play an important role if implemented correctly⚡️ We spoke to leading experts at Newcells to get their thoughts on the impact of AI for the industry. Read or listen to the interviews here: https://lnkd.in/ensdYzks #Newcells #AI #DrugDiscovery #BioTech

We investigated the consistency of human iPSC-derived retinal organoids (RO) produced at large scale by quantifying the gene and protein expression levels of key retinal cell markers across differentiation in multiple batches. The well-known limitations of in vivo and existing in vitro retinal models, a 3D in vitro model of the human retina which is reproducible and able to accurately predict in vivo outcomes is highly desirable. Find out more 👉 https://lnkd.in/eC_NQ_TM #Newcells #RetinalOrganoids #RetinaModels #InVivo #InVitro