John Stamos, Gina Gershon and Kelsea Ballerini Are Among the Buzzy Stars Boarding Doctor Odyssey in New Trailer

Expect a slew of familiar faces to pop up as guest stars on Doctor Odyssey.

Ryan Murphy's brand-new medical procedural, premiering Thursday, Sept. 26, stars Joshua Jackson as Max, a doctor aboard a luxury cruise ship called the Odyssey who navigates “unique medical crises” with the aide of his medical team “miles from shore," according to the synopsis. Doctor Odyssey’s cast includes Phillipa Soo, Sean Teale and Don Johnson; John Stamos, Gina Gershon, Kelsea Ballerini, Cheyenne Jackson and Chord Overstreet also appear as guest stars throughout the first season.

The new trailer opens with Jackson’s character examining a female patient while Johnson’s character proudly explains to Soo and Teale that he selected Jackson from a competitive pool of 110 applicants.  

In another scene, Johnson welcomes Jackson aboard the Odyssey, introducing him to Soo and Teale.

“You must be my brilliant nurses,” Jackson says.

“We are the ship’s brilliant and capable nurses. Yes.” Soo corrects him, eliciting an apology and a handshake from Jackson.

A sequence of scenes showcase passengers like Stamos, Jackson and Overstreet while Johnson declares via voiceover that the crew’s “mission” is to “preserve the dream.”

“And that’s why you’re here,” he adds.

The next montage teases the high-stakes medical situations Jackson, Soo and Teale encounter, followed by a tryst between Jackson and Soo.

Afterwards, the two awkwardly ride the elevator in silence before they ask each other whether they want to talk about “what happened.”

“No, no, no. I’m good,” Jackson says as Soo quickly replies, “Then great. Great.”

As the trailer offers more glimpses of the opulent experiences the Odyssey offers — including a grand ballroom with a disco ball, and a freewheeling beachside party — Johnson explains that while they’ve “constructed a paradise,” they have to be “prepared for everything.”

“It’s your job to keep everyone alive,” Johnson tells Jackson.

“I’m in,” Jackson responds.

A passenger tumbles overboard in the next scene, prompting a search led by Jackson.

“In life, it’s not a question of when you encounter waves, but when you do when they come up,” Johnson adds through voiceover.

The next scenes hint at several other challenges the Odyssey crew encounters, including a possible collision that has one crewmember hanging on as the ship tilts to the side.

“We’re becoming some kind of team, aren’t we?” Jackson asks Soo and Teale rhetorically, before the trailer cuts to the show’s title.

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Doctor Odyssey premieres Thursday, Sept. 26 at 9 p.m. ET on ABC.