Timothy Singowikromo

Exciting news! 🎆 We are happy to share the publication of the latest study by our colleague Eva Kimpe in Frontiers in Oncology! This model-based health economic evaluation examines the impact of late radiation-induced small bowel toxicity in rectal cancer survivors by comparing different radiotherapy techniques. 📈 The study highlights the societal cost of small bowel toxicity in this population 💶. With the use of health economic modeling techniques, Three-Dimensional Conformal Radiation Therapy (3D-CRT), Intensity Modulated Radiation Therapy (IMRT), and Intensity Modulated Radiation Therapy - Image Guided Radiation Therapy (IMRT/IGRT) were compared. 💡 The findings of the study reveal that advanced techniques, such as IMRT and IMRT/IGRT, substantially reduce the occurrence of small bowel toxicity events. This underscores the importance of considering late toxicity effects in health economic evaluations and decisions related to investments and reimbursement, demonstrating the potential for long-term cost savings and improved quality of life through the adoption of novel radiation techniques. Interested in learning more? Read the full text here: 🔗https://lnkd.in/ektj26fG #ICHER #REDM #VUB #Research #CancerSurvivorship #Oncology #HealthEconomics #Radiotherapy #RectalCancer

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Are you interested in networking with your peers and learning about #DrugDevelopment? There is STILL TIME to register for the BENELUX Drug Development Symposium 2.0 in Utrecht on 28 Nov. 2024. Where? Accelerator, Uppsalalaan 17, Utrecht Science Park, Netherlands Register here: https://gag.gl/WR2Ixf You will gain new perspectives on pitching to investors, receive insights from biotech leaders on drug development, AI in clinical trials, and the role of innovation and technology in sustainability and global health equity. #biotech #innovation #clinicaltrials #healthequity #sustainability

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📢 Come on! An excellent Systematic Review is now online! 📄 Title: Data science techniques to gain novel insights into quality of care: a scoping review of long-term care for older adults ✏ Authors: Ard Hendriks, Coen Hacking, Hilde Verbeek, Sil Aarts* 💌 This review reveals the limited use of data science techniques on data accumulated in or by LTC facilities. ✨ Want to read more? Please click: https://lnkd.in/gxxawiiq (P.S. Download as PDF for better viewing 👀 ) #ExplorDHT #bigdata #datascience #olderadults

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Together with a group of enthusiastic scientists, researchers, academics, regulatory and industrial partners (e.g. chiron) we have established the FIRST Roadmap on organ-on-chip devices! 📄 📄 More than 120 European experts worked on this exhaustive document for 2 years with the support of NEN! 🎉 This is not only a document helping people working in the field or simply interested in the subject navigating the complexity of organ-on-chip models but also the first step towards an ISO standardization of these models! 📝 We all know how these technologies are revolutionizing the way we address scientific questions. 👨‍🔬 👩‍🔬 Now we are looking at making them a standard that can be used in research setting with rules allowing increase user-friendliness and reproducibility. Thank you Andries van der Meer for being one of the main initiator of this major milestone in organ-on-chip technologies and Suzie Noten for supporting together with the rest of NEN! You can find more information here: https://lnkd.in/d7WRHk4E #technology #standsrdization #innovation #organonchip #advanced #invitro #technology #unite #milestone

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🤝 University of Twente and Radboudumc are going to cooperate more closely in the field of knowledge and talent development and innovation. The two academic institutions have signed a strategic cooperation agreement to this end. Under the name Healthtech Nexus, they are jointly committed to the "unmet need" of healthcare: urgent needs for which no good solutions yet exist. 🤖 Microrobots that swim through your blood vessels, organs on a chip, diagnostics with artificial intelligence: these are just a few examples of how modern technology and healthcare are becoming increasingly intertwined. It is precisely in these areas that the Radboudumc and the University of Twente have found each other. #healthtechnexus #technology #microrobots #ai #organsonachip #innovation #healthcare

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Hanze University of Applied Sciences in Groningen (The Netherlands) has conducted a feasibility study to investigate whether a Minimal Viable Product (MVP) of an #EHR can be realized with the available #opensource stack. The first conclusion is that the existing components need improvement, especially in the field of data exchange (such as FHIR). We are planning a webinar together with Hanze University of Applied Sciences regarding this study in September. If you are interested to participate, please leave your name in the comment or send a PM. #FHIR #openEHR #OMOP openEHR NL openEHR International openEHR UK openEHR SverigeMinisterie van Volksgezondheid, Welzijn en Sport Nictiz CumuluZ Santeon mProve ziekenhuizen RSO Nederland Nedap Healthcare HEALTH-RI Stichting HL7 Nederland NVZ | Nederlandse Vereniging van Ziekenhuizen VZVZ Microsoft Azure Better vitagroup Cambio Group Tietoevry DIPS AS CODE24 EY USoft pragmatiQ Sitra NFU - Nederlandse Federatie van Universitair Medische Centra Nederlandse Vereniging voor Klinische Informatica (NVKI) European Commission Maastricht UMC+ Zuyderland UMCG Zorginstituut Nederland Coöperatie VGZ CZ Zilveren Kruis Landelijke Huisartsen Vereniging (LHV) eFORZE HealthNoord #EHDS #MasterclassopenEHR

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Last week, our Research Assistant Michala Nordfalk attended the Frontiers in Cardiovascular Biomedicine meeting in Amsterdam, organized by the European Society of Cardiology. During the poster session, Michala presented a novel method developed at Minerva Imaging for inducing myocardial infarction using ultrasound guided electrocoagulation in rats. The results showed that it is possible to induce infarction without thoracotomy, and we are committed to continue the development of this method further. Interested in learning more about our capabilities within cardiovascular research? Visit our website to learn more: https://lnkd.in/e7T8-QyY #drugdevelopment #cardiovasculardiseases #myocardialinfarction

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🤖 How can AI help to improve healthcare? Dutch newspaper de Volkskrant interviewed UMC Utrecht’s Carl Moons, Ilse Kant and Carmen van Dooijeweert and showcased three ways in which AI is already making healthcare more efficient. 💝 The pathology department at UMC Utrecht, for instance, uses an AI model to search for breast cancer metastases. Carmen: “It saves time and money: from more than six minutes per tissue sample to under four minutes. We also need 30 percent fewer colorations, which makes the process less expensive.” 📖 Read more below. ⤵️ For more info on Carmen’s research (the CONFIDENT-B trial), please read https://lnkd.in/ep6WhnCc #AI #cancerresearch #breastcancer #pathology

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Excited to share that the article Jeroen Uleman and I have been working on is now published in GeroScience. Using data from the NILVAD study, we investigated the longitudinal effects of systemic inflammation and endothelial dysfunction on the rate of cognitive decline in patients diagnosed with mild-to-moderate Alzheimer’s Disease. We found no effects from various markers of systemic inflammation (TNF-α and IL-1ß) and endothelial dysfunction (E-selectin, ICAM-1, and VCAM-1) on the cognitive decline trajectories in these patients. Furthermore, our investigation did not substantiate any mediation or interaction effects for endothelial dysfunction. Our study's findings contribute to the existing literature regarding the ongoing discourse on AD’s etiology/progression and relevant biomarkers by suggesting that inflammatory markers (TNF-α and IL-1ß) and endothelial cell markers (E-selectin, ICAM-1, and VCAM-1) have neither cross-sectional nor longitudinal associations with cognitive decline in AD patients and that the role of these markers may need to be reconsidered. Also a special thanks to the co-authors who participated and collaborated on this project: Rianne de Heus Niels Riksen René Melis Jurgen Claassen and Brian Lawlor. Read the full text here: https://lnkd.in/eZw5hvSy

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📽 Maarten de Rooij, radiologist, and Henkjan Huisman, associate professor of AI in radiology, explain the role of AI in diagnosing prostate cancer. NFU - Nederlandse Federatie van Universitair Medische Centra campaign 'Let science work #medicalresearch #AI #innovativeresearch #prostatecancer #letsciencework

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Happy to share this nice paper from a work when I was still at LUMC. Congrats to the whole team, specially Ghazaleh Hajmousa, DVM, PhD. Niek Bloks , Yolande F. M. Ramos and Ingrid Meulenbelt This comprehensive study generate methylome-wide landscapes of hiPSC-derived neo-cartilage. By integrating transcriptome-wide data, we identified key dissimilarities in methylation set points, their transcriptional consequences, and the pathways these genes regulate. These findings are a step toward unraveling the complexities of hiPSC-derived cartilage and moving closer to real-world clinical solutions. #RegenerativeMedicine #hiPSCs #StemCellResearch #NeoCartilage #Epigenetics #ClinicalResearch #Methylation #multiomics #RNASeq #omics #dataintegration

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I am really happy to announce that our latest paper on chronic liver disease modelling is now online and published in Biofabrication! It is a collaborative effort by Laura Cools, Mina Kazemzadeh Dastjerd and several members of the Vrije Universiteit Brussel LIVR Lab & UZ Brussel. It is also the result of a longstanding collaboration with Catherine Verfaillie (KU Leuven). In this paper we independently differentiated human iPSCs towards hepatoblasts (iHepatoblasts), hepatic stellate cells (iHSCs), endothelial cells (iECs) and macrophages (iMΦ), before assembly into free floating spheroids. These iPSC-derived liver cultures can mount a fibrotic response due to hepatocyte injury, possibly eliminating the need for primary human liver samples. This opens doors to investigating pathways involved in human fibrosis development and to identify new targets for chronic liver disease therapy. This model could pave the way for patient-specific testing and potentially reduce reliance on animal models in drug discovery. Huge thanks to Catherine Verfaillie and congratulations to Laura Cools, Mina Kazemzadeh Dastjerd, and the entire LIVR Lab for this exciting work! This research was supported by Research Foundation Flanders - FWO. #biofabrication #liverdisease #personalizedmedicine #iPSCs #fibrosis #drugdiscovery #VUB VUB/UZB UMCOR https://lnkd.in/eDmPtnmm

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"besides qualitative methods and computational methods, the methodological approach for analyzing these books could benefit from the inclusion of the people who are closest to this dataset, namely patients and their relatives, as well as those directly affected, such as healthcare professionals." #citizenscience #mentalhealth #publicengagement #patients #methodologies #bigdata #learning

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In Conversation with the Change-Makers in AI & Healthcare Dialogues with Prof. Andre Dekker: Part 1 In this insightful first segment, Prof. Andre Dekker, a renowned Medical Physicist and Professor of Clinical Data Science Maastricht, introduces the revolutionary concept of the Personal Health Train—a transformative approach to AI training in healthcare. Using the Personal Health Train metaphor, he explains how AI algorithms travel to hospitals (stations), learn from their data, and return refined without transferring patient information. Join us at the AI Revolution in Healthcare Summit Dubai Feb 15 & 16 2025, to discover how concepts like the Personal Health Train are reshaping AI in medicine. Learn more: www.airh.one #AIRevolutionInHealthcare #Dubai2025 #HealthcareInnovation #DigitalHealthcare #Medvarsity #FutureOfMedicine  Assimilate by Medvarsity Medvarsity

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In Conversation with the Change-Makers in AI & Healthcare Dialogues with Prof. Andre Dekker: Part 1 In this insightful first segment, Prof. Andre Dekker, a renowned Medical Physicist and Professor of Clinical Data Science Maastricht, introduces the revolutionary concept of the Personal Health Train—a transformative approach to AI training in healthcare. Using the Personal Health Train metaphor, he explains how AI algorithms travel to hospitals (stations), learn from their data, and return refined without transferring patient information. Join us at the AI Revolution in Healthcare Summit Dubai Feb 15 & 16 2025, to discover how concepts like the Personal Health Train are reshaping AI in medicine. Learn more: www.airh.one #AIRevolutionInHealthcare #Dubai2025 #HealthcareInnovation #DigitalHealthcare #Medvarsity #FutureOfMedicine  Assimilate by Medvarsity Medvarsity

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In Conversation with the Change-Makers in AI & Healthcare Dialogues with Prof. Andre Dekker: Part 1 In this insightful first segment, Prof. Andre Dekker, a renowned Medical Physicist and Professor of Clinical Data Science Maastricht, introduces the revolutionary concept of the Personal Health Train—a transformative approach to AI training in healthcare. Using the Personal Health Train metaphor, he explains how AI algorithms travel to hospitals (stations), learn from their data, and return refined without transferring patient information. Join us at the AI Revolution in Healthcare Summit Dubai Feb 15 & 16 2025, to discover how concepts like the Personal Health Train are reshaping AI in medicine. Learn more: www.airh.one #AIRevolutionInHealthcare #Dubai2025 #HealthcareInnovation #DigitalHealthcare #Medvarsity #FutureOfMedicine  Assimilate by Medvarsity Medvarsity

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Optogenetics has transformed neuroscience, giving researchers a powerful tool to control brain activity with light. In this blog, Hana Hasanbegovic, Ph.D., Erasmus University Rotterdam, provides 5 practical tips for optimising your #optogenetics experiments 💡

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How to improve cardiovascular risk prediction and personalise care? Our latest research, with Folkert Asselbergs and colleagues at Amsterdam UMC delves into combining digital twinning and generalist AI models! Digital twins: 🖥️ As virtual replicas of patients, they integrate vast amounts of personalised data to simulate and analyse their real-world counterparts. Generalist AI Models: 🧠 These innovative AI models adapt to various medical tasks, providing precise medical reasoning and personalised health insights. This approach offers dynamic simulations of health outcomes, allowing patients and clinicians to make informed decisions on lifestyle changes and treatment options. 💡 📚 Read the full paper here: https://lnkd.in/dVEES2_Q #Cardiology #PersonalisedMedicine #AIinHealthcare #DigitalTwinning #HealthTech #AIinMedicine

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