Elizabeth Gordon

Elizabeth Gordon

Menaggio, Lombardia, Italia
1293 follower Oltre 500 collegamenti

Informazioni

A senior clinical neuroscientist specialising in neuroimaging biomarkers in…

Attività

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Esperienza

  • Grafico Qynapse
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    Italy

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    London, United Kingdom

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    London, England, United Kingdom

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Formazione

  • Grafico UCL

    UCL

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    This work involved a comprehensive comparison of longitudinal structural neuroimaging measures within the clinical, genetic and pathological frontotemporal dementia (FTD) subgroups. Effect and sample size estimates were computed to explore the feasibility of automated brain measures as surrogate markers of disease progression to detect disease-modifying treatment effects in clinical trials.

    Multiple techniques for extracting whole-brain, lobar and subcortical atrophy measures were…

    This work involved a comprehensive comparison of longitudinal structural neuroimaging measures within the clinical, genetic and pathological frontotemporal dementia (FTD) subgroups. Effect and sample size estimates were computed to explore the feasibility of automated brain measures as surrogate markers of disease progression to detect disease-modifying treatment effects in clinical trials.

    Multiple techniques for extracting whole-brain, lobar and subcortical atrophy measures were applied and significant differences in performance were found, highlighting the importance of informed biomarker choice.

    Measures of temporal lobe, caudate and thalamic atrophy proved to be particularly sensitive markers in patients. Importantly, increased amygdala, hippocampus, caudate and thalamic atrophy were detected in presymptomatic mutation carriers, providing the first comprehensive assessment of the utility of such subcortical markers for this early preclinical stage for therapeutic intervention.

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    This MSc was an excellent collaboration between the department of medicine and department of philosophy at UCL to provide a comprehensive overview not only of the medical sciences of clinical trials (all phases) and translational medicine, but to also address the ethical, regulatory and real-world experience of conducting clinical trials in human subjects and enforcing health standards, enforming health policy and understanding health regulations.

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Licenze e certificazioni

Esperienze di volontariato

  • Patient and Carer Support Group Facilitator

    Familial Dementia Support - UCL

    - 8 anni

  • STEM ambassador for London High School network

    Ada Lovelace Initiative - UCL

    - 4 anni

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