Elizabeth Gordon
Menaggio, Lombardia, Italia
1293 follower
Oltre 500 collegamenti
Informazioni
A senior clinical neuroscientist specialising in neuroimaging biomarkers in…
Attività
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A long trip away to Japan 🇯🇵 and China 🇨🇳 but putting best foot 🦶 foward for good old Blighty 🇬🇧….
A long trip away to Japan 🇯🇵 and China 🇨🇳 but putting best foot 🦶 foward for good old Blighty 🇬🇧….
Consigliato da Elizabeth Gordon
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A partnership that will enhance clinical care as well as optimise clinical trials! #icometrix #SEQSTER
A partnership that will enhance clinical care as well as optimise clinical trials! #icometrix #SEQSTER
Consigliato da Elizabeth Gordon
Esperienza
Formazione
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UCL
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This work involved a comprehensive comparison of longitudinal structural neuroimaging measures within the clinical, genetic and pathological frontotemporal dementia (FTD) subgroups. Effect and sample size estimates were computed to explore the feasibility of automated brain measures as surrogate markers of disease progression to detect disease-modifying treatment effects in clinical trials.
Multiple techniques for extracting whole-brain, lobar and subcortical atrophy measures were…This work involved a comprehensive comparison of longitudinal structural neuroimaging measures within the clinical, genetic and pathological frontotemporal dementia (FTD) subgroups. Effect and sample size estimates were computed to explore the feasibility of automated brain measures as surrogate markers of disease progression to detect disease-modifying treatment effects in clinical trials.
Multiple techniques for extracting whole-brain, lobar and subcortical atrophy measures were applied and significant differences in performance were found, highlighting the importance of informed biomarker choice.
Measures of temporal lobe, caudate and thalamic atrophy proved to be particularly sensitive markers in patients. Importantly, increased amygdala, hippocampus, caudate and thalamic atrophy were detected in presymptomatic mutation carriers, providing the first comprehensive assessment of the utility of such subcortical markers for this early preclinical stage for therapeutic intervention. -
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This MSc was an excellent collaboration between the department of medicine and department of philosophy at UCL to provide a comprehensive overview not only of the medical sciences of clinical trials (all phases) and translational medicine, but to also address the ethical, regulatory and real-world experience of conducting clinical trials in human subjects and enforcing health standards, enforming health policy and understanding health regulations.
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Licenze e certificazioni
Esperienze di volontariato
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Patient and Carer Support Group Facilitator
Familial Dementia Support - UCL
- 8 anni
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STEM ambassador for London High School network
Ada Lovelace Initiative - UCL
- 4 anni
Altre attività di Elizabeth
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Something that I have become extremely aware of as I have relied solely on open data since I work independently, and I don't quite know how or why it…
Something that I have become extremely aware of as I have relied solely on open data since I work independently, and I don't quite know how or why it…
Consigliato da Elizabeth Gordon
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#JFR2024 Nous sommes ravis de collaborer avec 123 CS un acteur incontournable dans le domaine de la santé ! Retrouvez notre équipe lors de…
#JFR2024 Nous sommes ravis de collaborer avec 123 CS un acteur incontournable dans le domaine de la santé ! Retrouvez notre équipe lors de…
Consigliato da Elizabeth Gordon
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Amyloid-lowering therapies remain controversial due to the occurence of ARIA but also ARPA - amyloid-removal-related pseudo-atrophy. In this paper we…
Amyloid-lowering therapies remain controversial due to the occurence of ARIA but also ARPA - amyloid-removal-related pseudo-atrophy. In this paper we…
Consigliato da Elizabeth Gordon
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Such an essential area in #alzheimersdisease. Once again demonstrating the value of exisiting infrastructure like #MRI #Diffusion and unlocking the…
Such an essential area in #alzheimersdisease. Once again demonstrating the value of exisiting infrastructure like #MRI #Diffusion and unlocking the…
Consigliato da Elizabeth Gordon
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What happenings if an individual with Alzheimer’s disease is also affected by α-synuclein pathology? In this Nature Communications paper we show…
What happenings if an individual with Alzheimer’s disease is also affected by α-synuclein pathology? In this Nature Communications paper we show…
Consigliato da Elizabeth Gordon
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The first clinical CT scan on a patient took place on 1st October 1971 at Atkinson Morley's Hospital in London. The patient, a lady with a suspected…
The first clinical CT scan on a patient took place on 1st October 1971 at Atkinson Morley's Hospital in London. The patient, a lady with a suspected…
Consigliato da Elizabeth Gordon
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Two new jobs in the Oxford-Novartis collaboration at the Big Data Institute & Oxford Statistics on Multiple Sclerosis - Looking for people with…
Two new jobs in the Oxford-Novartis collaboration at the Big Data Institute & Oxford Statistics on Multiple Sclerosis - Looking for people with…
Consigliato da Elizabeth Gordon
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