Kristóf Szalay
Budapest, Budapest, Hungary
1 E Követői
500+ kapcsolat
Rólunk
I believe that the most important contributions to today's science are the enabling tools…
Szakmai tapasztalat
Tanulmányok
Licencek és tanúsítványok
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Intangible Assets Management
Semmelweis Innovations
Issued -
Project Management
Pro-COMpass Kft.
Issued -
Extended Radiation Safety
Semmelweis University
Issued ExpiresCredential ID B-015/2012
Önkéntes tapasztalat
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EMT
Hungarian Charity Service of the Order of Malta, Ambulance Corps
- 1 év
Egészség
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Head organizer / organizer / tutor
SSSL
- 6 év 3 hónap
Tanulmányok
SSSL is a student organization of the Faculty of Electronics Engineering organizing multiple student events and generally helping freshmen integrate into the University.
Publikációk
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ComPPI: a cellular compartment-specific database for protein-protein interaction network analysis
Nucleic Acids Res. Database Issue
Here we present ComPPI, a cellular compartment-specific database of proteins and their interactions enabling an extensive, compartmentalized protein–protein interaction network analysis (URL: http://ComPPI.LinkGroup.hu). ComPPI enables the user to filter biologically unlikely interactions, where the two interacting proteins have no common subcellular localizations and to predict novel properties, such as compartment-specific biological functions. ComPPI is an integrated database covering four…
Here we present ComPPI, a cellular compartment-specific database of proteins and their interactions enabling an extensive, compartmentalized protein–protein interaction network analysis (URL: http://ComPPI.LinkGroup.hu). ComPPI enables the user to filter biologically unlikely interactions, where the two interacting proteins have no common subcellular localizations and to predict novel properties, such as compartment-specific biological functions. ComPPI is an integrated database covering four species (S. cerevisiae, C. elegans, D. melanogaster and H. sapiens). The compilation of nine protein–protein interaction and eight subcellular localization data sets had four curation steps including a manually built, comprehensive hierarchical structure of >1600 subcellular localizations. ComPPI provides confidence scores for protein subcellular localizations and protein–protein interactions. ComPPI has user-friendly search options for individual proteins giving their subcellular localization, their interactions and the likelihood of their interactions considering the subcellular localization of their interacting partners. Download options of search results, whole-proteomes, organelle-specific interactomes and subcellular localization data are available on its website. Due to its novel features, ComPPI is useful for the analysis of experimental results in biochemistry and molecular biology, as well as for proteome-wide studies in bioinformatics and network science helping cellular biology, medicine and drug design.
További szerzőkPublikáció megtekintése -
Attractor structures of signaling networks: Consequences of different conformational barcode dynamics and their relations to network-based drug design
Molecular Informatics
Conformational barcodes tag functional sites of proteins, and are decoded by interacting molecules transmitting the incoming signal. Conformational barcodes are modified by all co-occurring allosteric events induced by post-translational modifications, pathogen, drug binding, etc. We argue that fuzziness (plasticity) of conformational barcodes may be increased by disordered protein structures, by integrative plasticity of multi-phosphorylation events, by increased intracellular water content…
Conformational barcodes tag functional sites of proteins, and are decoded by interacting molecules transmitting the incoming signal. Conformational barcodes are modified by all co-occurring allosteric events induced by post-translational modifications, pathogen, drug binding, etc. We argue that fuzziness (plasticity) of conformational barcodes may be increased by disordered protein structures, by integrative plasticity of multi-phosphorylation events, by increased intracellular water content (decreased molecular crowding) and by increased action of molecular chaperones. This leads to increased plasticity of signaling and cellular networks. Increased plasticity is both substantiated by and inducing an increased noise level. Using the versatile network dynamics tool, Turbine (www.turbine.linkgroup.hu), here we show that the 10% noise level expected in cellular systems shifts a cancer-related signaling network of human cells from its proliferative attractors to its largest, apoptotic attractor representing their health-preserving response in the carcinogen containing and tumor suppressor deficient environment modeled in our study. Thus, fuzzy conformational barcodes may not only make the cellular system more plastic, and therefore more adaptable, but may also stabilize the complex system allowing better access to its largest attractor.
További szerzők -
Cancer stem cells display extremely large evolvability: alternating plastic and rigid networks as a potential mechanism
Seminars in Cancer Biology
Cancer is increasingly perceived as a systems-level, network phenomenon. The major trend of malignant transformation can be described as a two-phase process, where an initial increase of network plasticity is followed by a decrease of plasticity at late stages of tumor development. The fluctuating intensity of stress factors, like hypoxia, inflammation and the either cooperative or hostile interactions of tumor inter-cellular networks, all increase the adaptation potential of cancer cells. This…
Cancer is increasingly perceived as a systems-level, network phenomenon. The major trend of malignant transformation can be described as a two-phase process, where an initial increase of network plasticity is followed by a decrease of plasticity at late stages of tumor development. The fluctuating intensity of stress factors, like hypoxia, inflammation and the either cooperative or hostile interactions of tumor inter-cellular networks, all increase the adaptation potential of cancer cells. This may lead to the bypass of cellular senescence, and to the development of cancer stem cells. We propose that the central tenet of cancer stem cell definition lies exactly in the indefinability of cancer stem cells. Actual properties of cancer stem cells depend on the individual "stress-history" of the given tumor. Cancer stem cells are characterized by an extremely large evolvability (i.e. a capacity to generate heritable phenotypic variation), which corresponds well with the defining hallmarks of cancer stem cells: the possession of the capacity to self-renew and to repeatedly re-build the heterogeneous lineages of cancer cells that comprise a tumor in new environments. Cancer stem cells represent a cell population, which is adapted to adapt. We argue that the high evolvability of cancer stem cells is helped by their repeated transitions between plastic (proliferative, symmetrically dividing) and rigid (quiescent, asymmetrically dividing, often more invasive) phenotypes having plastic and rigid networks. Thus, cancer stem cells reverse and replay cancer development multiple times. We describe network models potentially explaining cancer stem cell-like behavior. Finally, we propose novel strategies including combination therapies and multi-target drugs to overcome the Nietzschean dilemma of cancer stem cell targeting: "what does not kill me makes me stronger".
További szerzők -
Perturbation Centrality and Turbine: A Novel Centrality Measure Obtained Using a Versatile Network Dynamics Tool
PLoS ONE
Analysis of network dynamics became a focal point to understand and predict changes of complex systems. Here we introduce Turbine, a generic framework enabling fast simulation of any algorithmically definable dynamics on very large networks. Using a perturbation transmission model inspired by communicating vessels, we define a novel centrality measure: perturbation centrality. Hubs and inter-modular nodes proved to be highly efficient in perturbation propagation. High perturbation centrality…
Analysis of network dynamics became a focal point to understand and predict changes of complex systems. Here we introduce Turbine, a generic framework enabling fast simulation of any algorithmically definable dynamics on very large networks. Using a perturbation transmission model inspired by communicating vessels, we define a novel centrality measure: perturbation centrality. Hubs and inter-modular nodes proved to be highly efficient in perturbation propagation. High perturbation centrality nodes of the Met-tRNA synthetase protein structure network were identified as amino acids involved in intra-protein communication by earlier studies. Changes in perturbation centralities of yeast interactome nodes upon various stresses well recapitulated the functional changes of stressed yeast cells. The novelty and usefulness of perturbation centrality was validated in several other model, biological and social networks. The Turbine software and the perturbation centrality measure may provide a large variety of novel options to assess signaling, drug action, environmental and social interventions.
További szerzőkPublikáció megtekintése -
Network-based tools in the identification of novel drug-targets.
Science Signaling
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An optical method for rapid screening of blood-borne pathogens
Electronics Technology, 2009. ISSE 2009. 32nd International Spring Seminar
In clinical laboratory work, blood samples are the most common body material used in daily diagnostic tasks. Donated blood needs to be screened for blood-borne diseases before it can be used. This procedure currently takes about twelve hours of laboratory work, and that is acceptable in the case of blood donations. However, the same verification needs to be done in the case of organ transplantations where a 12-hour wait is way too long. Utilizing the currently most sensitive label-free…
In clinical laboratory work, blood samples are the most common body material used in daily diagnostic tasks. Donated blood needs to be screened for blood-borne diseases before it can be used. This procedure currently takes about twelve hours of laboratory work, and that is acceptable in the case of blood donations. However, the same verification needs to be done in the case of organ transplantations where a 12-hour wait is way too long. Utilizing the currently most sensitive label-free biosensor technology-surface plasmon resonance (SPR)-with a CCD imaging approach allows the construction of a device capable of fast and sensitive detection of blood-borne pathogens. In this paper, a prototype of such an SPR imaging device is presented. Some of the considerations that allow reaching the needed sensitivity and the prototype measurement results are described as well. The completed system was tested with two materials of different optical density, PBS (phosphate buffered saline) and water, at 20degC and 40degC (near-room and near-body temperatures).
További szerzőkPublikáció megtekintése
Tanfolyamok
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Artificial Intelligence
BerkeleyX (edx.org)
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EIT Health Innovation & Business Summer School
Trinity College & IESE
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Epigenetic Control of Gene Expression
U.Melbourne(coursera.org)
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Heterogeneous Parallel Programming
U.Illinois (coursera.org)
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Intangible Assets Management
Semmelweis Innovations
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International Summer School on Network Science
FuturICT Group
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Introduction to Data Science
U. Washington (Coursera)
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Introduction to Systems Biology
Icahn Med. (coursera.org)
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Learning from Data
Caltech (online)
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Programmed cell death
LMU München(coursera.org)
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Project Management
Pro-COMpass Kft.
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Quantum Mechanics and Quantum Computation
BerkeleyX (edx.org)
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StratCan Summer School on Network Science
Karolinska Instituet
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Web Intelligence and Big Data
IIT Delhi (coursera.org)
Kitüntetések és díjak
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MIT Tech Review 35 Innovators under 35 Europe 2018
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https://www.innovatorsunder35.com/the-list/kristof-szalay/
"Cécile Tharaud, Vice President for Innovation at the NAOS Group and member of the jury of Innovators Under 35 Europe 2018, considers Szalay’s project "exceptional" and believes that he stands out as someone "creative, intelligent, tenacious, ambitious, pragmatic and balanced". For the judge, this young man has been at the centre of a "sharp, specific and realistic” business adventure in a field that represents "one of the main…https://www.innovatorsunder35.com/the-list/kristof-szalay/
"Cécile Tharaud, Vice President for Innovation at the NAOS Group and member of the jury of Innovators Under 35 Europe 2018, considers Szalay’s project "exceptional" and believes that he stands out as someone "creative, intelligent, tenacious, ambitious, pragmatic and balanced". For the judge, this young man has been at the centre of a "sharp, specific and realistic” business adventure in a field that represents "one of the main challenges of modern medicine: personalised medicine"." -
Bayer Grants4Apps accelerator
Bayer AG
Our company, Turbine has been selected to the top 4 from 405 applicants to participate in Bayer's 100-day Grants4Apps accelerator program.
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Semmelweis Innovation Prize
Semmelweis University
The Innovation Prize of the Semmelweis University is awarded each year for the most innovative clinical research, basic research, PhD and student project work. The reason for the award was the Turbine project.
Nyelvek
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Hungarian
Anyanyelvi vagy kétnyelvű szintű nyelvismeret
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English
Magas szintű szaknyelvi ismeret
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French
Alapfokú nyelvismeret
További hasonló profilok
Egyéb megnevezett Kristóf Szalay
3 mások a Kristóf Szalay LinkedIn-en vannak
Lásd a többi nevet Kristóf Szalay