Paul-Etienne Jacob

'Healthcare platform Doctolib has conquered France — but can it take on Europe?' Lloyd Price, HealthTech M&A Advisor and Partner at Nelson Advisors shares his thoughts with Daphné Leprince-Ringuet from Sifted discussing Doctolib, their continued success, big future and potential next moves. 'Few startups in France can claim to have changed the way people behave in as systemic a way as Doctolib. Launched in 2013 by Stanislas Niox-Chateau, Doctolib has become a key component of the country’s healthcare system. Its first product — an online booking platform that lets patients schedule doctor appointments — saw huge adoption in a sector with very little digitisation. > Today, the company covers “almost all of the French population”, says Doctolib’s CFO Pierre Vergnes. It counts 80m patient accounts spanning three countries, of which the vast majority remains in France. Doctolib also has 19m users in Germany, which it expanded to in 2016, and a “nascent” number of users in Italy, launched in 2021. > During the Covid pandemic, the French government selected the company as an official partner to manage vaccination appointments. “[In France], they’re a utility company for running healthcare infrastructure now,” says Lloyd Price, a healthtech M&A advisor. Mergers, Acquisitions, Growth and Strategy for Healthcare Technology companies > HealthTech M&A - Buy Side, Sell Side, Growth & Strategy services for companies in Europe, Middle East and Africa. Visit www.nelsonadvisors.co.uk > HealthTech M&A Newsletter from Nelson Advisors - HealthTech, Health IT, Digital Health Insights and Analysis. Subscribe Today! https://lnkd.in/e5hTp_xb > Healthcare Technology Buy Side, Sell Side, Growth & Strategy services for Founders, Owners and Investors. Email [email protected] > Healthcare Technology Thought Leadership from Nelson Advisors – Market Insights, Analysis & Predictions. Visit https://lnkd.in/ezyUh5i https://lnkd.in/edDCqmrz

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💪 We are very proud to have been included among the #key #startups in #digital #health who are helping to #combat #medical #deserts. Since CONCILIO's creation, we have been helping companies find solutions to support their employees' health in France and in more than 64 other countries. Our #unique #medical #concierge service offers : ✅ #Teleconsultation, 24/7, in five languages. ✅ #Digital #health #checkups focused on general health, women's health, mental health, and more. ✅ Daily support by #recommending #top #specialists endorsed by their peers to prevent medical wandering. ✅ #Medical #appointment #booking with general practitioners and specialists to save time and reduce the mental load for employees and their families, particularly those living in medical deserts. #digitalhealth #telemedecine #telehealth #bestdigitalhealthcompany #concilio #medicalconcierge

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Looking forward to sharing my perspectives and hearing how others are approaching the global VC landscape at this session at #GRIC2024!

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Introducing the Game-Changing MRI Iseult 🚀 I want to share an advancement that will have a major impact on our understanding of psychiatric and neurodegenerative diseases: the MRI Iseult. 🕰 After two decades of tireless research, the French CEA laboratory has unveiled a state-of-the-art device with an unprecedented resolution of 11.7 teslas. It is three times more precise than standard models. To view the article click here 👉 https://lnkd.in/ewv-PGWP 🧬This achievement heralds a new era in neurology and medical R&D, promising advances in deciphering the complexities of the human brain. Thanks to its unrivaled precision, visionary entrepreneurs will translate their aspirations into tangible advances in understanding the brain. The Iseult MRI holds the key to understanding diseases such as Alzheimer's, Parkinson's and psychiatric disorders. This MRI will also improve our knowledge of the role of lithium in the treatment of schizophrenia and bipolar disorder. This innovation will enable startups to develop new products and services. This is precisely the idea behind Newfund’s latest initiative, Heka, a VC fund dedicated to supporting startups leveraging biological data linked to the brain to enhance our health. In this particular domain, so important for us as individuals and for our species since the brain plays such a role for Sapiens, there is no innovation without a deep understanding of the latest scientific discoveries. Tools such as Iseult are a major help for this endeavor. Newfund is humbled to be part of this adventure, in its modest place. cc Marion Leboyer, Veronique Briquet-Laugier, Michael Jackson, Anne-Sophie Saint-Martin, Constant Beroulle #Heka #MRI #BrainHealth #deeptech #Innovation #Research #Neurology #Breakthrough

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🔍 France's Medtech sector is at a pivotal moment...In 2023, financial sponsor exits in French healthcare totaled just €141M compared to €1.3B in Germany and €8.1B in the US! Despite its rich history in medical innovation, the lack of local private equity investment is holding back promising companies. France currently accounts for 14% of the European medical device market but lags behind Germany’s 27%. The good news? There’s a backlog of mature French medtech firms generating revenues of €20M to €30M that are ready to scale up, but they need more local growth capital. Upcoming deals, such as Astorg’s stake in Echosens and Theravia’s exit pipeline, highlight the potential waiting to be unlocked. With the new European Commission expected to simplify regulations, the question remains: how can we harness PE support to ensure France's medtech sector thrives? Source : ION Analytics, Med Tech Europe #Healthcare #Medtech #Privateequity #Investments #France ——— I am Alexis - French pharmacist turned entrepreneur. My company BTHT is connecting senior industry experts, ex-payors, and KOLs with consultants and investors in Life Sciences and Healthcare for expert calls and senior advisory. Join 16K+ followers by clicking my name + follow 🔔 Join 1.4K+ subs to my weekly newsletter 💌

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A shocking diagnosis has just been made in China: a 19-year-old young man is said to be suffering from Alzheimer's disease. This discovery calls into question our knowledge of this pathology. How can we explain the early onset of this neurodegenerative disease? What implications for medical research? -- > NOT A SURPRISE ?.. BECAUSE INFECTIONS (LYME & CO) MAY TRIGGER THESE KIND OF DISEASES (stated in studies since 2006.. and till 2024) https://lnkd.in/earXTbj3 --------------------------- Updates in Alzheimer's disease: from basic research to diagnosis and therapies Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disorder, characterized pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and intracellular accumulation of hyperphosphorylated tau (pTau) as neurofibrillary tangles. Clinically, AD patients show memory deterioration with varying cognitive dysfunctions. The exact molecular mechanisms underlying AD are still not fully understood, and there are no efficient drugs to stop or reverse the disease progression. In this review, we first provide an update on how the risk factors, including APOE variants, infections and inflammation, contribute to AD; how Aβ and tau become abnormally accumulated and how this accumulation plays a role in AD neurodegeneration. Then we summarize the commonly used experimental models, diagnostic and prediction strategies, and advances in periphery biomarkers from high-risk populations for AD. Finally, we introduce current status of development of disease-modifying drugs, including the newly officially approved Aβ vaccines, as well as novel and promising strategies to target the abnormal pTau. Together, this paper was aimed to update AD research progress from fundamental mechanisms to the clinical diagnosis and therapies. https://lnkd.in/etyf-ZmD ----------- Un diagnostic bouleversant vient d'être posé en Chine : un jeune homme de 19 ans serait atteint de la maladie d'Alzheimer. Cette découverte remet en question nos connaissances sur cette pathologie. Comment expliquer l'apparition si précoce de cette maladie neurodégénérative ? Quelles implications pour la recherche médicale ? https://lnkd.in/eWXaGhMX

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💥 Focus Adhérent : découvrez Vaiomer 💥 As demonstrated in abundant literature from the last decades, the gut microbiome and bacterial translocation are involved in the dysregulation of the immune system, and inflammation, and play a crucial role in numerous chronic diseases. 🧬Vaiomer is a company with extensive experience and specialized methods and reagents for analyzing microbiome in low-biomass samples, including blood and tissue biopsies, with a contamination-aware approach. 🔎 Learn more: https://lnkd.in/eHWwVGfm 🔧 We develop advanced methods to address these challenges, ensuring accurate and reliable microbiome analysis. 📚 Over 100 articles have been published in different fields based on microbiome data generated by Vaiomer. 🔬Vaiomer also offers services including scientific and technical reports, molecular applications and bioinformatics development & analyses. For further discussion: [email protected] #Microbiome #GutHealth #ChronicDisease #Bioinformatics #Innovation #Healthcare #Vaiomer #ScientificResearch

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Diagnosis is an amazing art that requires Deep knowledge on Everything Related to the Human Condition ! 👇 " The human condition can be defined as the characteristics and key events of human life, including birth, learning, emotion, aspiration, reason, morality, conflict, and death. This is a very broad topic that has been and continues to be pondered and analyzed from many perspectives, including those of art, biology, literature, philosophy, psychology, and religion." https://lnkd.in/g-Qv-63x 👇 You have to a true POLYMATH to be a great doctor 👇 "A polymath is a person who knows a lot about a lot of subjects. If your friend is not only a brilliant physics student but has also published a poetry collection and won prizes at political debates, you can describe her as a polymath" https://lnkd.in/gwmmprKp 👇 GOOGLE Search Prompt Link on all articles on the Art of Diagnosis :' NOTHING REQUIRES MORE LEADERSHIP THAN ATTAINING PROPER DIAGNISTICS AND PROGNOSTICS ABILITY AS A DOCTOR, SCIENTIST AND LEADER OF HUMANS. https://lnkd.in/gRY_9vZD 👇 Main Article Link :- https://lnkd.in/gnxrtkJJ " The art of diagnosis: solving the clinicopathological exercise " Abstract We analyzed the psychological process by which physicians solve complicated diagnostic problems, such as those posed in clinicopathological exercises. The challenge of differential diagnosis is to select the most probable cause of a patient's condition, yet the size of the problem, the nature of medical information, and the notorious inability of human beings to manipulate probabilities in their heads all conspire against the diagnostician to make it virtually impossible to employ Bayes' theorem in routine diagnosis. Unable to estimate the desired probabilities explicitly, physicians recast the problem into a form that uses one of their most effective mental skills--that of comparing patterns. A study of 50 clinicopathological conferences published in the Journal suggests that the following six steps are taken to arrive at a diagnosis: aggregation of groups of findings into patterns, selection of a "pivot" or key finding, generation of a cause list, pruning of the cause list, selection of a diagnosis, and validation of the diagnosis. Although the clinicopathological conference differs in some important ways from real-life diagnostic problems, we believe that the principles described here closely resemble those used in practice. Properly selected clinicopathological conferences are excellent windows through which to study diagnostic reasoning. PubMed Disclaimer D M Eddy et al. N Engl J Med. 1982 👇 LINK TO ALL ARTICLES ON DIAGNOSIS :- 👇 https://lnkd.in/gPfx2hta

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👨‍🎓 [#ETFInvesting] | Not all Exchange Traded Products (ETPs) are the same... If you want to know the differences between Exchange Traded Funds (ETFs) and Exchanged Traded Commodities (ETCs), download our guide to the Exchange Traded Product Family⤵ https://lnkd.in/e-gw7PfT #ETFbasics

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🇫🇷 #1 Gx company BIOGARAN is said to be on sale. But is it really and who are the potential buyers? YES Servier needs (more) money. They had to pay a €430m fine last year following the mediator scandal in France. And YES they are pursuing an agressive (and quite successful) inorganic growth strategy acquiring high profitability assets in oncology 💸 Financial wise the group finances are exceptional, reaching in 2 years €5.3B (+20%) of revenue and €1B of EBITDA (+59%) representing 19% of revenue and next year objectives continuing on the same trend. BUT while its France Gx 💊 affiliate Biogaran reached €924m in sales in 2022, its EBITDA margin was only of 7%… Despite serving 30% of the French Gx market in volume, it is estimated that 1/3 of their molecules are generating losses…😅 “C’est là qu’est l’os” NOW Who are the potential buyers? As of now, candidates include: - Torrent Pharmaceuticals Ltd; the $1.2B Indian actor specializing in Gx and member of the Torrent conglomerate (gas, power, pharma) - AUROBINDO PHARMA LTD; the other rapidly growing $3.3B Indian actor specializing in Gx with a strong appetite for overseas markets and deep pockets - BC Partners, the renowned private equity fund greatly experienced in healthcare, and notably owning the French food supplements group Havea - And word on the street also includes the €40m (?) French industrial CMO BENTA Lyon (ex FAMAR sites from KKR), now independent from its Lebanese holding Benta, and which would partner with a solid investor… Will France government intervene? What are the real risks for the French patients? Who is really at risk? Story to be continued…📖 Let me know if you want to receive my take on it (spoiler: I have some ideas already) ——— I am Alexis - French pharmacist turned entrepreneur. My independant and fully bootstrapped company BTHT is a global expert network serving the strategy consulting firms and private equity investors in the life sciences sector. Like my content? Click my name + follow + 🔔

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Anti-Aging Anti-Aging is a dermis call if you were to simplify it from a scientific term ; notably as the fresh growth from protein and new skin skill during the turn-over rate - in accordance to healthy DNA and RNA. DNA, is unique ; RNA, are meant to suppress your responsive system with possible of fatigue and other side effect - that's able to reverse our innate build with strength on the symptom for which we in wish to discontinue under either long term and short term basis ; similiar like a coding transcript, notably as side effect. RNA : https://lnkd.in/gjXKCXnf Anti-Aging, however ; is a series of agile control process, with respect on the speed for skin cell turn over-rate and renewal process - such as, wrinkle brought by overly laugh and dramatic facial expression as it fissure the collagen barrier much often than usual. Most of the Anti-Aging product were interference by collagen extract and bacteria activation such as hyaluronic acid ; or forensic procedure like botox to induce production of protein. I am not a medical professional, but all my statement were being made based on personal believe and experience after working in the industry for many years ; I was in a position where every selling product is surely good and effective, so then it brought me such a wonder that how good or well it could possibly be at the optimum aspect with great suspect and genuinely expressed it through a new consumer's lens - particularly with my recent Spiritual Practitioning, realizing that it seemed none of the chemical ingredient or pharmaceutical product will ever good for our body ; and I was on the path in provide with some basic information based on logical finding plus some research, with minimal courtesy being a non medical practitioner or sponsored elaborator in hope to driving for genuine business. As per my understanding, all product seemed to have altered so many chemical compound although beneficial, and suppressing our immune system embodiment ; which certainly alerted me with great concern and feel the need to voice out. If you are a medical professional, scientist or nutritionist feeling the need to rectify my statements, kindly proceed ; or otherwise the relevant embodiment shall run adequate patrol unto any information published in ensuring for safety - with due concern that all information available online may not be correct, definitely. This would certainly bring awareness to all industry, in driving for creative awakening phase on how to be much genuine before engage new business development ; I personally feel that this kind of integrity level and dare to construct mistake by a trial with error spirit, is fairly important to my career adventure. In such movement, I will be able to realigning my motivation with higher self-awareness while picking the right company to work with. I understood the level of frustration you might be having ; so do I - perhaps, is time for us to slow down pace together. Let's fair our journey.

English interview with Pierre-Edouard Sottas. Pierre-Edouard has a PhD, and is the Founder and CEO of xLongevity. With expertise in physics, biology, life sciences, and AI, Pierre-Edouard focuses on improving biomarker testing for accurate measurements and meaningful insights. One of his key achievements is developing the biological passport, which helps people understand their personal biological data. He has held leadership roles in multiple startups, all aimed at promoting healthier lives. As a dedicated biohacker, Pierre-Edouard continually explores ways to enhance personal well-being, believing that true longevity means living a fuller, healthier life. For my community xLongevity.com is offering a discount code. Just head on xlongevity.com, and use the coupon code SALUTE  to get 10% off on all their supplements. Takeaways 👉 Biohacking is about taking control of one's health 👉 Health is defined as vitality and feeling good 👉 Preventative medicine is key to longevity NAD+ plays a crucial role in aging and metabolism 👉 Personalized health monitoring empowers individuals 👉 Tracking health metrics over time is essential 👉 xLongevity aims to provide holistic health solutions 👉 Collaboration with experts enhances service offerings 👉 Quality and efficacy of supplements are prioritized 👉 The future of health management lies in personalization My “Salute e Biohacking” Podcast is available on Spotify, Apple Podcast, and YouTube. Find out more about myself and my Podcast on my webpage: 👉 https://thehappyfew.com/en If you are a fan of this Podcast please help me spread it to as many people as possible. I explain how to rate the Podcast, write a review or make a donation on my website. 🎧 Let me know if you enjoyed the interview! 🚀🐺🙋‍♀️ Vanessa ❤️💪 #biohacking #longevity #health #optimalhealth #science #technology #NAD #biomarkers #supplements #xlongevity https://lnkd.in/d7wZAXvq

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The next pole of #medtech innovation in Europe! Nextmed Strasbourg in Strasbourg, #grandest, is set to expand.... in number of startups, projects in research, and integration of AI in medical devices. MedTech Europe EIT - European Institute of Innovation and Technology

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🚨Le poids d’une dette non remboursée! 🫀🫁🧠You may be familiar with the consequences of debt in general, but are you aware of the fatal consequences of oxygen debt for the body? When the body experiences oxygen debt, it cannot supply sufficient oxygen to vital organs, leading to serious health issues. In critical situations—such as shock, trauma, or respiratory failure—this can result in life-threatening conditions. This shift to anaerobic metabolism results in the accumulation of lactic acid, causing lactic acidosis. 🏃🏻‍➡️Prolonged oxygen deprivation can lead to multi-organ failure, causing vital organs like the heart and brain to fail, resulting in severe outcomes such as cardiac arrest or brain damage. The longer the body remains in an oxygen-deprived state, the higher the risk of fatal outcomes, making rapid intervention critical. 🗣️🗣️🗣️To mitigate these risks, it is essential to transition quickly from first Aid to advanced care. 🗣️🗣️🗣️Which involves Rapid establishing vascular access (venous and or arterial) and administering appropriate medications to restore oxygen supply to the body’s tissues. ✅Sononurse is dedicated to addressing these challenges by providing innovative bedside medical devices that facilitate rapid interventions,in Primary Care, reducing oxygen debt and improving survival outcomes in critical situations. ✅Quick Link: Rapid Access, Lifesaving Solutions. #Centech #TransMedTech #MSSS #FMSQ #POCUS #Ultrasound #APSF #ISMP #Angel #CNRC #Angel

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Investment Idea: The Healthcare Industry - Driving Growth and Stability The healthcare sector remains resilient and rapidly expanding, driven by aging populations and rising chronic diseases. Global healthcare spending is growing, with innovations in personalised medicine, digital health, and biotechnologies pushing boundaries and positioning the sector for long-term growth. The U.S. healthcare market is highly attractive for investment due to its size, flexible pricing, and steady demand. As a non-cyclical sector, healthcare offers stability across economic cycles, making it resilient in downturns. With increasing healthcare needs, this demand is unlikely to wane, presenting strong growth opportunities for investors. Technological advancements in pharmaceuticals, biotech, and medical devices are transforming patient care and unlocking new revenue streams. Companies like GSK, Roche, and Merck are well-positioned to capitalize on these trends. Demographic shifts, such as the global aging population, reinforce the sector’s robust long-term outlook. Healthcare stocks are traditionally viewed as defensive, offering stability in volatile markets. GSK, Roche, and Merck have a proven track record of weathering economic storms. For the proposed note offering a 10% coupon, the S&P 500 would have to statistically experience an unprecedented 56% drop before breaching the proposed barrier level of the product —underscoring healthcare’s strength as a reliable investment in uncertain times. If you wish to gain access to the full presentation of the idea, do not hesitate to contact our team: Romain Duchenne: [email protected] Hugo Poupinel: [email protected] For more information on our company, please access the website below: https://lnkd.in/eFBWjTG4

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💥 Don't forget your #TITANWeekly! Special topics this week:  - Onion case with McDonalds  - New origin logo from ‘le collectif en verite’  - New app from Agricolus S.r.l.  - Concern about Ultra Processed Foods (UPFs) is growing — but is processing really the problem? 👇 Let us know your thoughts in the comments

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