Aurore THION

Lyophilized Injectable Drugs Market Overview The global Lyophilized Injectable Drugs market is estimated to be worth over USD 5,833.17Mn in 2033 and is expected to grow at CAGR of6.2% during the forecast period (2024-2033). Lyophilized injectable drugs, also commonly named as freeze-dried drugs, can be defined as pharmaceutical formulations that have been processed through lyophilization, a technique of dehydration that conserves the drug in a stable, solid state. This process includes freezing the drug solution and eradicating water under vacuum, led in a lyophilized cake that can be restored with a solvent, usually sterile water, before administration via injection. Lyophilized injectable drugs provide several advantages, including improved stability, extended shelf life, and reduced risk of degradation compared to liquid formulations. These drugs are commonly used for the treatment of various medical conditions, including infections, cancer, autoimmune diseases, and hormonal imbalances, among others. Free PDF for Complete Information - https://lnkd.in/g5twSsYh

📃Scientific paper: Cangma Huadu granules, a new drug with great potential to treat coronavirus and influenza infections, exert its efficacy through anti-inflammatory and immune regulation Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Coronavirus and influenza virus infection seriously threaten human health. Cangma Huadu Granules (CMHD) is an in-hospital preparation composed of eight traditional Chinese medicines (TCM), which has been clinically used against COVID-19 in China and may be a promising candidate for the treatment of influenza. However, the role of its treatment urgently needs to be studied. Aim of the study: To evaluate the therapeutic effects of CMHD on pneumonia induced by coronavirus (HCoV-229E) and influenza A virus (H1N1/FM1) in mice and explore its mechanism of anti-infection. MATERIALS AND METHODS: Mice were infected with HCoV-229E or H1N1/FM1 virus through the nasal cavity. CMHD (12.1, 6.05 and 3.03 g/kg/d) or the positive control drugs were administered intragastrically. The lung index and histopathological changes were used to evaluate the therapeutic effect of CMHD. The expression of TNF-α, IL-1β, IL-6 and IL-4 in Serum and the proportion of CD4(+) and CD8(+) T lymphocytes in peripheral blood were detected to evaluate the anti-inflammatory and immune regulation effects of CMHD, respectively. Furthermore, the levels of p–NF–κBp65/ NF-κB p65, which was the key targets of the NF-κB pathway was analyzed. RESULTS: In HCoV-229E-induced pneumonia, the lung index was markedly reduced, and lung pathology was improved in mice that treated with CMHD (12.1, 6.05 g/kg/d). Meanwhile, the expression of TNF-α, IL-6 were obviously inhibited, but the expres... Continued on ES/IODE ➡️ https://etcse.fr/WKOAI ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

[Nature] | Anti-viral defence by an mRNA ADP-ribosyltransferase that blocks translation Here, the author characterizes the widely distributed anti-phage defense system CmdTAC, which provides robust defense against infection by the T-even family of phages. Research reveals a novel mechanism of anti-viral defense and a previously unknown but broadly distributed class of ADP-ribosyltransferases that target mRNA. https://lnkd.in/g4MSVWpU https://lnkd.in/gd6pBX_H #NatureResearch #mRNA #ADPribosyltransferase #AntiviralDefense #PhageResistance #CmdTAC #TEvenPhages #Alphalifetech

🍭#DIABETE: Part2 🚽 #Urinary_Control: Glycosuria and Ketonuria The aim of this control is to detect glucose, and in the case of type 1 diabetes, ketone bodies in urine using reactive strips. These strips are immersed in urine, and glucose/ketone presence is visually assessed based on color changes. 🩸 #Blood_Glucose_Control Long-term diabetes complications are directly related to the duration of diabetes and average blood glucose levels. Hence, diabetic patients must learn self-monitoring techniques to adjust factors affecting blood glucose levels (insulin doses, diet, etc.). Self-monitoring involves obtaining a drop of capillary blood using a lancet, applying it to a test strip or electrode, and reading blood glucose levels using a glucometer. Glycemic self-monitoring is essential for successful insulin therapy and therapeutic regimen adjustment. Ideally, four blood glucose measurements should be taken daily, corresponding to each meal injection, accompanied by a control at a variable time, usually 2 hours after a meal or before bedtime. 🔍 #Lancets Some lancets allow adjusting puncture depth based on finger thickness and skin quality. Other devices (e.g., Freestyle Papillon Mini, Accu-chek Active) enable puncturing less vascularized areas, though results may not always align with fingertip readings. Usage Tips: ●Wash and dry hands before puncturing. ●Avoid alcohol use as it toughens the skin and may skew results. ●Prefer finer needles (0.2 mm) and change them after each puncture. ●Opt for puncturing the side of the finger, less sensitive than the pulp. ●Avoid using the thumb and index finger. ●Do not share or exchange equipment. 📰 #Glucose_Readers_and_Strips All devices have been tested by health authorities for optimal accuracy (±20%). Some prioritize speed, simplicity, and portability, while others, more sophisticated, can connect to a computer to print results and statistical data. Most require only a small blood drop for reading. Usage Tips: ●Follow calibration and maintenance guidelines specific to each device. ●Adhere to the recommended reaction time (specific to each reader). ●Pay attention to units expressed in mmol/L or g/L. ●Check the expiration date of strips. ●After use, close the strip container and store it away from light and moisture. ●Use strips compatible with the reader. ●Do not use dirty strips. Note: Continuous glucose recording systems are available to monitor glucose fluctuations over several days, evaluating overall glycemic patterns throughout the day. These include Continuous Glucose Monitoring Systems (CGMS), using a subcutaneous electrode connected to a recording system, and Glucoday glucose sensors, operating based on microdialysis principles.

Advancements in COVID-19 Vaccination: Safety and Immunogenicity Results from the GEMCOVAC-OM StudyGennova Biopharmaceuticals (India) recently conducted a multicenter, open-label, randomized Phase 2 and 3 study to evaluate the safety and immunogenicity of GEMCOVAC-OM, a novel Omicron-specific (B.1.1.529) monovalent, thermostable, self-amplifying mRNA vaccine that is administered intradermally as a booster in healthy adults who had previously received two doses of either BBV152 or ChAdOx1 nCoV-19. The results revealed a robust safety profile, with no serious adverse events reported, indicating that the vaccine is well tolerated. In Phase 2, GEMCOVAC-OM induced significantly higher anti-spike IgG titers and seroconversion rates compared to the prototype vaccine, GEMCOVAC-19. In the Phase 3 trial, which included 3,140...

📃Scientific paper: Development and validation of a novel diagnostic tool for predicting the malignancy probability of thyroid nodules: A retrospective study based on clinical, B-mode, color doppler and elastographic ultrasonographic characteristics Abstract: BACKGROUND: Clinicians estimate the risk of thyroid nodules and make subsequently decision on the basis of clinical and ultrasonographic findings. Currently, there is no comprehensive diagnostic tool for predicting the malignancy rates of thyroid nodules. Our aim was to develop and validate a novel integrate diagnostic tool for predicting the malignancy probability of thyroid nodules based on clinical, B-mode, Color Doppler and elastographic ultrasonographic characteristics. METHODS: A total of 1016 nodules in 1016 patients who underwent thyroid ultrasonography and surgery from July 2021 to December 2021 were included in this retrospective study. All nodules were confirmed by pathology and randomly classified into the training and validation groups. Clinical, B-mode, Color Doppler and elastographic (CBCE) ultrasonographic characteristics of nodules were recorded. Univariate and multivariate analyses were performed to screen independent predictors associated with thyroid cancer. A multivariate model containing the extracted predictors was constructed and presented in the form of a nomogram. The validation and applicability of the CBCE nomogram was evaluated using the receiver operating characteristic (ROC) curve. Diagnostic performances were calculated to compare the CBCE nomogram with ACR-TIRADS (Thyroid Imaging Reporting Data System by American College of Radiology) and EU-TIRADS (Thyroid Imaging Reporting Data System by European Thyroid Association). RESULTS: Th... Continued on ES/IODE ➡️ https://etcse.fr/xIfm ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Development and validation of a novel diagnostic tool for predicting the malignancy probability of thyroid nodules: A retrospective study based on clinical, B-mode, color doppler and elastographic ultrasonographic characteristics Abstract: BACKGROUND: Clinicians estimate the risk of thyroid nodules and make subsequently decision on the basis of clinical and ultrasonographic findings. Currently, there is no comprehensive diagnostic tool for predicting the malignancy rates of thyroid nodules. Our aim was to develop and validate a novel integrate diagnostic tool for predicting the malignancy probability of thyroid nodules based on clinical, B-mode, Color Doppler and elastographic ultrasonographic characteristics. METHODS: A total of 1016 nodules in 1016 patients who underwent thyroid ultrasonography and surgery from July 2021 to December 2021 were included in this retrospective study. All nodules were confirmed by pathology and randomly classified into the training and validation groups. Clinical, B-mode, Color Doppler and elastographic (CBCE) ultrasonographic characteristics of nodules were recorded. Univariate and multivariate analyses were performed to screen independent predictors associated with thyroid cancer. A multivariate model containing the extracted predictors was constructed and presented in the form of a nomogram. The validation and applicability of the CBCE nomogram was evaluated using the receiver operating characteristic (ROC) curve. Diagnostic performances were calculated to compare the CBCE nomogram with ACR-TIRADS (Thyroid Imaging Reporting Data System by American College of Radiology) and EU-TIRADS (Thyroid Imaging Reporting Data System by European Thyroid Association). RESULTS: Th... Continued on ES/IODE ➡️ https://etcse.fr/xIfm ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Development and validation of a novel diagnostic tool for predicting the malignancy probability of thyroid nodules: A retrospective study based on clinical, B-mode, color doppler and elastographic ultrasonographic characteristics Abstract: BACKGROUND: Clinicians estimate the risk of thyroid nodules and make subsequently decision on the basis of clinical and ultrasonographic findings. Currently, there is no comprehensive diagnostic tool for predicting the malignancy rates of thyroid nodules. Our aim was to develop and validate a novel integrate diagnostic tool for predicting the malignancy probability of thyroid nodules based on clinical, B-mode, Color Doppler and elastographic ultrasonographic characteristics. METHODS: A total of 1016 nodules in 1016 patients who underwent thyroid ultrasonography and surgery from July 2021 to December 2021 were included in this retrospective study. All nodules were confirmed by pathology and randomly classified into the training and validation groups. Clinical, B-mode, Color Doppler and elastographic (CBCE) ultrasonographic characteristics of nodules were recorded. Univariate and multivariate analyses were performed to screen independent predictors associated with thyroid cancer. A multivariate model containing the extracted predictors was constructed and presented in the form of a nomogram. The validation and applicability of the CBCE nomogram was evaluated using the receiver operating characteristic (ROC) curve. Diagnostic performances were calculated to compare the CBCE nomogram with ACR-TIRADS (Thyroid Imaging Reporting Data System by American College of Radiology) and EU-TIRADS (Thyroid Imaging Reporting Data System by European Thyroid Association). RESULTS: Th... Continued on ES/IODE ➡️ https://etcse.fr/xIfm ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.