Alain Toledano

Conclusions This study provided randomized data on the beneficial effect of dapagliflozin in nondiabetic patients with HFrEF and HFmrEF in terms of myocardial performance measured by the most sensitive echocardiographic technique, ie, STE. This suggests its usefulness for left ventricular reverse remodeling and better quality of life in patients with HFrEF and HFmrEF. (Effects of Dapagliflozin on cardiac deformation and clinical outcomes in heart failure with reduced and mildly reduced ejection fraction [DAPA ECHO trial]; EudraCT number: 2021-005394-66)

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📰 [ABSTRACT] Analysis of >174k working age people (≤62 years old) initiating CPAP therapy in 2015/2016 for #ObstructiveSleepApnoea in the French national health insurance reimbursement database reveals that >22% of people stopped CPAP treatment within the first year. Stopping CPAP treatment was associated with long-term sick leave (i.e., ≥15 days absence) leading to permanent work disability. • This association was confirmed in an adjusted multivariable Cox model which indicated a 21% increased risk of permanent work disability with treatment cessation vs treatment continuation (hazard ratio: 1.21 [95% confidence interval 1.04, 1.41; p=0.01]) • The risk was 41% higher for those aged >55 years (hazard ratio: 1.41 [95% confidence interval: 1.06, 1.87; p=0.02]) In summary, continuation of CPAP therapy for the treatment of OSA is associated with a reduction in the proportion of individuals with long sick leave leading to permanent work disability, especially in the over 55-year age group. 👉 https://lnkd.in/eVXuSJqT #WeeklyResNews

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Can patients be co-researchers in #patientexperience? The answer is Yes: A wonderful article on building a PREM in cystic fibrosis with parents of patients as co-researchers.  https://lnkd.in/dYx35ES5

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🔥 𝗘𝗥𝗔𝗦 𝗶𝗻 𝗖𝗮𝗿𝗱𝗶𝗮𝗰 𝗦𝘂𝗿𝗴𝗲𝗿𝘆: 𝗥𝗲𝗱𝗲𝗳𝗶𝗻𝗶𝗻𝗴 𝘁𝗵𝗲 𝗦𝘁𝗮𝗻𝗱𝗮𝗿𝗱 𝗼𝗳 𝗖𝗮𝗿𝗲 𝗳𝗼𝗿 𝘁𝗵𝗲 𝟮𝟭𝘀𝘁 𝗖𝗲𝗻𝘁𝘂𝗿𝘆 🔥 Discover our ERAS program in cardiac surgery, featuring key perioperative protocols and an overview of our published results in JTCVS and EJCTS. 👉 Learn how our innovative approach is transforming patient outcomes and setting new benchmarks in the field of cardiac surgery. SFCTCV Société SavanteSFAR - Société française d'anesthésie et de réanimation EACTS - European Association for Cardio-Thoracic Surgery American Association for Thoracic Surgery (AATS) #CardiacSurgery #ERAS #HealthcareInnovation #SurgicalExcellence #PatientCare

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In the neoadjuvant setting, the meta-analysis supported the use of an ICI alongside chemotherapy in patients with TNBC and HR–positive, HER2–negative disease, but not among patients with HER2–positive disease. In the adjuvant setting, the analysis revealed no significant survival advantage among patients who continued ICI therapy after surgery, regardless of whether patients achieved a pCR or had residual disease. Neoadjuvant Immune Checkpoint Inhibitors Plus Chemotherapy in Early Breast Cancer: A Systematic Review and Meta-Analysis JAMA Oncol. 2024;10(10):1331-1341. doi:10.1001/jamaoncol.2024.3456

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Immune checkpoint inhibitors in people with HIV - outcomes analysed in a French cohort. 140 people, 65 with lung cancer, around 60% with positive CMV serology. Incidence of grade 3 or higher AEs and factors associated illustrated below. Survuvavl superior in people with CD4 >100 vs less and higher for Hodkin Disease and cutaeneous melanoma than other cancer types. No significant change in CD4, CD8 or ratio over time. Conclusion: ICI treatment has no impact on HIV control with no disruptions in control of viral repliaction and no decrease in CD4 T cell count. Very clear presentation from Jean-Philippe SPANO #HIVglasgo #hivglasgow2024

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Good morning ! The first lecture of the day….#IAPRD2024 Lisbon, Portugal Aniti-alpha synuclein and anti-tau immunotherapies: Can a cocktail approach work ? By Yaroslau Compta Highlights • a-synuclein and 4R-tau aggregates often coexist in synucleinopathies and tauopathies. • Anti-Synuclein and anti-tau immunotherapies are being tested in clinical trials. • Increasingly reliable biomarkers foreseeably will allow to assess in vivo co-pathologies. • A cocktail immunotherapy targeting both a-synuclein and 4R-tau is conceivable. Full article: https://lnkd.in/gJ4wwawX IAPRD Secretariat

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🌏 #International start of the SALVOVAR/ENGOT-ov78 study : after #France, we are now happy to announce the first patient at the international level and this is a Japanese #patient ! We are impatient to see the other countries starting soon (Italy, Israël and Netherlands and Czech Republic). SALVOVAR : A pragmatic randomized phase III trial to assess the utility of adjusting chemotherapy dose & dosing schedule with the SALVage weekly dose-dense regimen in patients with poor prognostic OVARian cancers based on the tumor unfavorable primary chemosensitivity and incomplete debulking surgery.

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A classical epithelial state drives acute resistance to KRAS inhibition in pancreas cancer https://lnkd.in/eqwADZD4

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Le débat du type de fluides à administrer aux patients dans un état critique fait l'objet de la première partie d'une trilogie rédigée par European Society of Intensive Care Medicine. On peut notamment y lire (je cite): Isotonic saline (normal saline, 0.9% saline) is tradition- ally the most commonly used crystalloid solution world- wide [2, 73]. Because isotonic saline contains sodium and chloride in equal concentrations (each 154 mmol/l), the strong ion difference is zero [3, 74]. As a result, rapid administration of a large volume of isotonic saline can cause hyperchloremic metabolic acidosis. It is recognized now that hyperchloremia may be associated with acute kidney injury [3, 74, 75]. ... Unresolved questions and research gaps There is a need to compare the effect of different balanced solutions, e.g., PlasmaLyte, Ringer’s lactate or acetate and others on patient-centered outcomes. Trials of guided therapy with balanced crystalloids and isotonic saline are an important next step for critically ill patients. Such trials could, for example, include regular chloride measurements, allowing for prompt intervention in case of hyperchloremia. Additionally, such trials could consider cost variations of fluids and laboratory tests across different settings. #paramedic #acutecare #ambulance

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📢 #specialissue #CallforPapers Oncologie new special issue“ Development of Integrative Oncology at the International and in France”is open for submission now. 📆 Submission Deadline:   30 October 2025 👨‍🎓 Guest Editors Dr. Alain Toledano, Institut de Cancérologie Hartmann, Centre de Radiothérapie Hartmann, Levallois-Perret, France 📝 The Special Issue invites articles, reviews, commentaries, perspectives etc. relating to Integrative Oncology from all over the world. Keywords for this Special Issue are: • Alternative and integrative medicine • cancer prevention • complementary • global health • health policy • survivorship • cancer • complementary health approaches • integrative oncology • lifestyle • integrative health 📚 Original research articles, review articles, case reports, commentaries and rapid-communications are welcome for this special issue (https://lnkd.in/exiwPA_H).

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Melanoma screening: who and when ? Please have a look at this great editorial in the JEADV by Effie Soura and Alexander Stratigos posing the problem of the lack of efficiency of melanoma screening in the general population and the need to define the "high-risk population" of patients who should undergo melanoma screening by dermatologists. https://lnkd.in/gVQhzaMp #melanoma #skincancer #skincancerscreening #dermatologist #dermatology #JEADV

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Interesting new research study showing how Nexstim nTMS data could potentially be used as biomarkers for multiple sclerosis disease progression. For MS patients, this study demonstrates how nTMS may provide objective metrics to track disease progression, offering them a clearer understanding of their condition and its development over time. For physicians, this could mean new precise biomarkers to improve diagnostic accuracy and help them to objectively distinguish between different forms and stages of MS. This isn't an FDA cleared use of nTMS but it will be interesting to see how this line of research develops! #multiplesclerosis #nTMS

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https://lnkd.in/ezSq99hq At Genoscience, women's health is important! Prenato and Genolife are here to meet all women's health needs. Dr. Jean Gekas CMO, Genoscience

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Pr. Grégoire Wuerzner, CHUV | Lausanne university hospital Switzerland was the principal investigator of Aktiia’s pivotal #clinicaltrial. The results of the study showed that the Aktiia solution is as accurate as a cuff and allows #patients and #physicians to track their #bloodpressure daily. The study data also showed Aktiia to be accurate in multiple body positions including sitting, lying and standing, and across a range of demographic factors including the Fitzpatrick skin tones 1-6.   This data enabled Aktiia to gain the CE Mark as a Class IIa #Medicaldevice in the non-invasive blood pressure monitors category since December 2020.   Combining the accuracy demonstrated in this pivotal study, with patient preference data collected in numerous other studies where Aktiia has shown to be a preferable solution for patients vs traditional BP cuff (96% of cases), means that Aktiia is the perfect solution for any research program in the need of 24/7 clinically valid BP datasets. To read more about this study visit https://lnkd.in/edXd8SAu   To speak to our expert Martin McMullan to learn more about the accuracy of Aktiia's blood pressure technology for #clinicalresearchers and #healthcareprofessionals

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important review to rise awareness how ever screening program is the master

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