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Association of Dental Fluorosis with Polymorphisms of Estrogen Receptor Gene in Chinese Children

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Abstract

Dental fluorosis (DF) is one of the important performances of endemic fluorosis. Some studies indicated that estrogen receptor (ESR) gene polymorphisms were associated with bone metabolism-related diseases. Therefore, it is possible that the variation in ESR genotypes will be associated with DF status. A case–control study was conducted among children aged 8–12 years with (n = 75) or without (n = 165) DF in China to investigate the relationship between ESR gene polymorphisms and DF. Gene polymorphisms were genotyped using the PCR-RFLP procedure. Children carrying R allele of ER RsaI had significantly increased risk of DF (Odds ratio (OR) = 1.821; 95% confidence interval (CI), 1.013–3.274) compared to children carrying r allele of ER RsaI in endemic fluorosis villages. For children with high-loaded fluoride status, carrying X allele of ESRα XbaI had a significantly decreased risk of DF (OR = 0.542; 95% CI, 0.314–0.936) compared to carrying x allele. This study provides the first evidence of an association between polymorphisms in the ESR gene with DF in high-fluoride-exposed populations. Further studies are needed to confirm the association.

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Acknowledgments

The work was supported by the NSFC grant 81072247 from the National Natural Science Foundation of China and by the grant 10PTGG380-12 from the Science and Technology Bureau of Zhengzhou City, Henan Province. The authors thank all individuals who volunteered to participate in this study and numerous members of the Zhengzhou University School of Public Health and Kaifeng Center for Disease Prevention and Control.

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Authors and Affiliations

  1. Department of Environmental Health, Zhengzhou University School of Public Health, 100 Science Road, Zhengzhou, Henan, 450001, People’s Republic of China

    Yue Ba, Huizhen Zhang, Gang Wang, Shibao Wen, Jingyuan Zhu, Haixia Li, Xuemin Cheng & Liuxin Cui

  2. Kaifeng Center for Disease Prevention and Control, Kaifeng, Henan, 475000, People’s Republic of China

    Yuejin Yang, Lijun Ren & Rupu Yang

  3. Sichuan University School of Public Health, Chengdu, Sichuan, 610041, People’s Republic of China

    Cairong Zhu

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  1. Yue Ba
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Correspondence to Yue Ba.

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Ba, Y., Zhang, H., Wang, G. et al. Association of Dental Fluorosis with Polymorphisms of Estrogen Receptor Gene in Chinese Children. Biol Trace Elem Res 143, 87–96 (2011). https://doi.org/10.1007/s12011-010-8848-1

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  • DOI: https://doi.org/10.1007/s12011-010-8848-1

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