Cardio-Pulmonary Institute

🏆 Stefan Ahlgrimm wins the poster prize on clinical/patient-oriented research at the 7th Science Day at Justus-Liebig-Universität Giessen’s Medical Department. His work explores therapeutic strategies for idiopathic pulmonary fibrosis - a severe chronic lung disease. #LungHealth #Science #Award

Highlights from the Science Day at Justus-Liebig-Universität Giessen’s Medial Department. 🔬✨ 19 early-career scientists from the CPI presented their research in poster sessions and lightning talks. From regenerative medicine to the future of AI in diagnostics, the day was packed with innovative research and inspiring networking! #ScienceDayJLU 🏆👏 A special shoutout to Stefan Ahlgrimm for winning the poster prize on clinical/patient-oriented research with his work on therapeutic strategies for idiopathic pulmonary fibrosis!

I am truly honoured and delighted of being awarded an honorary doctorate (Doctor medicinae honoris causa) from the Goethe University Frankfurt, Germany, one of the most prestigious universities for biomedical studies, in recognition of my work on RNA therapeutics for cardiac repair and regeneration. The Goethe University Cardio-Pulmonary Institute (#Stefanie Dimmeler) and  Institute for Vascular Signalling (#Ingrid Fleming) stand as beacons for research and advanced education in the cardiovascular field. #King's College London #Università degli Studi di Trieste #ICGEB

👏 Congratulations to Professor Mauro Giacca on receiving an honorary doctorate at the Goethe-Universität Frankfurt “Dies Academicus” ceremony, in recognition of his exceptional contributions to #Molecular #Biology. His groundbreaking work has significantly advanced the fields of gene therapy, stem cell research, cardiovascular disorders, and infectious diseases. Throughout his career, Professor Giacca has held numerous prestigious leadership roles. He has served as Professor of Molecular Biology at the Università degli Studi di Trieste, Italy, Professor of Cardiovascular Sciences at the King's College London, UK and Director-General of the International Centre for Genetic Engineering and Biotechnology (ICGEB). Among his most remarkable achievements is the identification of a crucial #microRNA promoting heart regeneration, along with the discovery of unexpected novel targets for cardiac repair (Ruozi et al, Science Translational Med 2022; Eulalio et al, Nature 2012; Lesizza et al Circ Res. 2017; Gabisonia et al, Nature. 2019).

Zum aktuellen Stand der Krebsforschung – Minisymposium von LOEWE-iCANx, 27. November 2024, Biomedizinischen Forschungszentrum Seltersberg, der JLU-Gießen Am 27. November 2024 lädt der LOEWE-Schwerpunkt iCANx, von 14:30 bis 17:30 Uhr, zum Minisymposium an das Biomedizinische Forschungszentrum Seltersberg (BFS), der Justus-Liebig-Universität Giessen, nach Gießen ein. Hochrangige Wissenschaftler wie Frank Winkler, Maria Llamazares Prada, Gergana Dobreva und Thorsten Zenz präsentieren Vorträge zu aktuellen Themen der #Krebsforschung. Dabei werden verschiedene Aspekte beleuchtet, von der epigenetischen Regulierung und #Stoffwechselveränderungen bis hin zu neuen Ansätzen in der #Krebsneurowissenschaft und der gezielten #Wirkstoffforschung Die Wissenschaftlerinnen und Wissenschaftler freuen sich auf einen inspirierenden Nachmittag mit tiefen Einblicken in innovative Forschungsansätze und die Möglichkeit zum Austausch. Minisymposium von LOEWE-iCANx, 14:30-17:30 Uhr, BFS kleiner Hörsaal B1, Schubertstraße 81, Gießen, keine Anmeldung erforderlich. #LOEWE_Forschungsfördeung #Grundlagenforschung #Hessen Philipps-Universität Marburg Max Planck Society Deutsches Zentrum für Lungenforschung (DZL) Cardio-Pulmonary Institute #Lungenkrebs #Tumorbiologie #Tumormikromilieu #Organmikromilieu #Lungenerkrankungen #PräklinischeModelle #Tumormetabolismus

Scientific excellence at Goethe University: Six researchers are among the best in the world! 🌍 According to the current “Highly Cited Researchers” ranking by Clarivate, six researchers at our university are among the most cited researchers worldwide. This is an important indicator of the relevance and quality of their scientific work - and proof of the excellent research taking place at our university. The ranking includes around 6600 researchers from all over the world who are among the 1% most frequently cited in their respective subject area or interdisciplinary field. The high citation frequency shows that their publications are not only recognized internationally, but are also used and further developed by colleagues in the long term. → The evaluation is based on the “Web of Science” database and includes articles from the natural sciences, engineering, medicine, social sciences and economics that have been published in the last ten years. It only takes into account scientific journal articles - i.e. results that have been published accurately and peer-reviewed. The “Highly Cited Researchers” of our university at a glance: 🔬 Prof. Dr. Ivan Đikić - Institute of Biochemistry II (IBC2), expert in molecular cell biochemistry in the categories “Biology and Biochemistry” and “Molecular Biology and Genetics” ❤️ Prof. Dr. Stefanie Dimmeler - Institute for Cardiovascular Regeneration, Speaker of the Cluster of Excellence Cardio-Pulmonary Institute (CPI), awarded for her interdisciplinary research (“Cross Field”) 🧬 Prof. Dr. Florian Greten - tumor biologist and director of the Georg-Speyer-Haus, also listed in the “Cross Field” category 🧪 Prof. Dr. Gerhard Hummer - Institute of Biophysics, Director at the Max Planck Institute, “Cross Field” category apl. Prof. Dr. med. Sibylle Loibl - GBG Forschungs GmbH, outstanding in “Clinical Medicine” Prof. Dr. Stefan Offermanns - Center for Molecular Medicine, represented in the “Cross Field” category We are proud of this success and congratulate our “Highly Cited Researchers”! 🎉 🔗 Further information can be found here: https://lnkd.in/ezk9TyAK. #GoetheUni #Science #HighlyCitedResearchers #Research #Excellence #Researchers #Ranking #Clarivate #WebOfScience

💡🌍 Wie entstehen echte Innovationen für die Gesundheit? 🔍🫀 Das Cardio-Pulmonary Institute (#CPI) bringt Forschende aus Grundlagen- und Anwendungsforschung zusammen und schafft so neue Möglichkeiten, Wissen zu verknüpfen. Im aktuellen Forschungsvideo erfahrt ihr, wie das CPI-Team daran arbeitet, innovative Therapien für Herz und Lunge zu entwickeln und Forschungsergebnisse in die Praxis zu überführen. "The main idea was to combine basic research with applied research—to take new ideas from the bench and see if they hold true when applied to patients." – Prof. Dr. Werner Seeger, Prof. Dr. Susanne Herold 🔍🫀 The Cardio-Pulmonary Institute (CPI) unites researchers from basic and applied science, creating new opportunities to combine insights. Our new research video provides a closer look at how CPI’s team is advancing innovation in heart and lung health, bridging discoveries to patient care. #JLU #Exzellenzstrategie #Forschung #Herzgesundheit #Lungengesundheit #Innovation Goethe-Universität Frankfurt

🚀🚀🚀 Fantastic team effort to discover the role of ubiquitination and selective autophagy in combatting defective splicing now published in Science: A team around Institute of Biochemistry II (IBC2) Director Ivan Đikić and Cristian Prieto-Garcia reveals how cells deploy ubiquitin-proteasome system and ER-phagy to combat the harmful effects of cryptic splicing, protecting against accumulation of misfolded proteins and preserving cellular health. #Splicing is a precisely regulated process facilitated by the #spliceosome, a large protein complex composed of more than 200 proteins. Defects in this dynamic process cause diseases such as retinitis pigmentosa (#RP), a genetic disorder that leads to progressive retina degeneration due to aberrant splicing in photoreceptor cells. 🔬The team around Đikić now discovered a novel mechanistic link between the deubiquitinase #USP39 and impaired RNA splicing. Using zebrafish and cellular models, they demonstrated that USP39 depletion mimics RP-like phenotypes with retinal degeneration. USP39 deficiency led to activation of cryptic 5’ splice sites, resulting in the production of aberrant protein isoforms that are prone to misfolding and aggregation. The misfolded proteins and protein aggregates disrupt cellular proteostasis and trigger cellular stress responses. 🔬 The team analyzed the repertoire of stress responses following USP39 depletion and found that cells ramped up #ubiquitination and #ERphagy, a specialized form of selective #autophagy targeting the endoplasmic reticulum (ER). By this, misfolded proteins can be removed and ER stress alleviated. If the proteotoxic burden cannot be successfully managed, then this leads to prolongation of ER stress, activation of the unfolded protein response (UPR), and, ultimately, apoptotic cell death. ➡ The result highlights the central role of the ubiquitin and autophagy systems in the pathology of spliceosome-associated diseases such as RP. They also suggest that enhancing protein degradation pathways could serve as a therapeutic approach to mitigate the toxic effects of cryptic splicing which was associated with multiple diseases, such as Alzheimer's.   🙏 🎉 Thanks to the international team for this great collaboration! 🙏 🎉 Goethe-Universität Frankfurt, Senckenberg Nature Research, Institute of Molecular Biology (IMB), SRCSB - Stuttgart Research Center Systems Biology, Max Planck Institute of Biophysics, Max Planck Institute for Heart and Lung Research, Johannes Gutenberg-Universität Mainz, EMBL, 中国科学技术大学, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Kyushu University PROXIDRUGS Zukunftscluster, SFB 1177, ProLOEWE, #ENABLE, DZHK Deutsches Zentrum für Herz-Kreislauf-Forschung e. V., Cardio-Pulmonary Institute, #TRR267, Innovation Center TheraNova Bundesministerium für Bildung und Forschung, Deutsche Forschungsgemeinschaft (DFG) - German Research Foundation, #HMWK, Max Planck Society, Schwiete Stiftung, Fraunhofer Gesundheit, #SCALE

💓🫁 Was passiert, wenn Forschende ihre Stärken bündeln? 🔍🫀 Am Cardio-Pulmonary Institute (#CPI) zeigt sich, welche Chancen im gemeinsamen Forschen stecken. Hier arbeiten Expertinnen und Experten der #JLU, der Goethe-Universität Frankfurt und des Max-Planck-Instituts für Herz- und Lungenforschung Hand in Hand. Die Forschenden verbinden ihr Wissen zu beiden Organen und haben so die einzigartige Möglichkeit, gemeinsame Muster zu erkennen, um innovative Therapieansätze zu entwickeln. Was genau das CPI ist, wie die Expertinnen und Experten vorgehen und was das mit der #Exzellenzstrategie der #JLU zu tun hat, erklären wir hier: ⬇️ --- 🇬🇧 💓🫁 What happens when researchers join forces? 🔍🫀 The Cardio-Pulmonary Institute (CPI) demonstrates the power of collaborative research. Here, experts from #JLU, Goethe-Universität Frankfurt, and the Max Planck Institute for Heart and Lung Research work hand in hand. By combining their knowledge of these two organs, researchers gain unique insights to recognize common patterns and develop innovative therapeutic approaches. Learn more about the CPI, the research process, and its connection to the #JLU #ExcellenceStrategy here: ⬇️ Fotos: JLU/Rolf Wegst

👏 Lingampally and colleagues from the Institute for Lung Health identified a subcluster of activated myofibroblasts (aMYFs) that may have significant implications the future management of idiopathic pulmonary fibrosis (IPF). #PaperOfTheMonth   IPF is a progressive, irreversible lung disease characterized by excessive extracellular matrix deposition. From a cell biology perspective, aMYFs are thought to secrete extracellular matrix and drive structural remodeling. Using genetic lineage tracing and single-cell transcriptomics, Lingampally and colleagues investigated the origin of aMYFs and their differentiation trajectories during the process of fibrosis formation and resolution.   For the first time, the researchers demonstrate the heterogeneity of aMYFs, identifying subclusters with differing roles - some exhibit distinct pro-alveologenic, while others pro-fibrotic properties. Lipofibroblasts play a major role in emergence and fate of aMYFs during fibrogenesis and resolution, respectively. This work provides new insights into the cellular dynamics of IPF and may inform future therapeutic strategies to treat or reverse fibrosis.  #IPF #LungHealth #Fibrosis #PrecisionMedicine #LungDisease Find the full article here: https://lnkd.in/ek3VtBfB