Exploration of Immunology

📢Newly Published Sharing: Impact of TP53 mutations on the efficacy of CAR-T cell therapy in cancer #review 👥 Authors: Regina Mirgayazova, Raniya Khadiullina, Maria Filimonova, Vitaly Chasov, Emil Bulatov 🔑 Keywords: #TP53 #mutation #CAR-T #immunotherapy #cancer 🎯 "......This review examines the link between TP53 mutations in cancer and the efficacy of CAR-T therapy, as well as the potential implications of this aspect in therapeutic planning." 👤 Academic editor: Cunte Chen, South China University of Technology, China 🔗 Read More: https://lnkd.in/gpr_fQGj

📢Newly Published Sharing: Association of genetic variations of interleukin-6 polymorphism (rs1800795) with susceptibility to Hashimoto’s thyroiditis in West Algerian population hashtag #OA 👥 Authors: Nawal Labiad, Moussa Messatfa, Youcef Bouali-Youcef, Houria Kadiri, Nardjess Ouikhlef 🔑 Keywords: Hashimoto's thyroiditis, IL-6, SNP, polymorphism, West Algeria #SNP #Hashimoto #thyroiditis 🎯 "Conclusions: This study reports no significant difference in IL-6 (-174 G/C) gene polymorphism at the allelic or the genotypic level between Hashimoto’s patients and the control group (P > 0.05). No association between the SNP IL-6 rs1800795 and susceptibility to Hashimoto’s thyroiditis in Western Algerian population." 👤 Academic editor: Margherita Sisto, University of Bari Medical School, Italy 🔗 Read More: https://lnkd.in/gzUSeFzJ

📢Newly Published Paper Sharing: Influence of puberty stage in immune-inflammatory parameters in well-trained adolescent soccer-players, following 8-weeks of pre-seasonal preparation training #OA 👥 Authors: Marios Hadjicharalambous, Eleanna Chalari, Nikolaos Zaras 🔑 Keywords: #Soccer, pre-seasonal training, immune responses, puberty stages, training adaptations #training 🎯 "Aim: The immune system can experience temporary suppression following acute or prolonged strenuous exercise, potentially increasing susceptibility to infections. Young athletes, who must balance school, training, studies, and social life, may further disrupt their immune-inflammatory responses. This study aimed to investigate the effects of an 8-week pre-season training on circulating leukocyte responses in well-trained adolescent soccer-players at different stages of puberty." 👤 Academic editor: Hassane Zouhal, University of Rennes 2 – Upper Brittany Rennes, France 🔗 Read the full article: https://lnkd.in/gE4BnMGt

📢Newly Published Paper Sharing: Plant derived bioactive compounds for the treatment of neurodegeneration and neuroimmune disorders associated with the complement system hashtag#review 👥 Authors: Jeyaparthasarathy Narayanaperumal, Ganesh Gopal 🔑 Keywords: #Complement systems, #neurodegeneration, neuroimmune disorders, #phytochemicals, #therapeutic 🎯 "......In this review, we summarized the current knowledge on the roles of the complement system in human neurodegenerative disorders and the benefits of natural compounds for complement-targeted therapy." 👤 Academic editor: Calogero Caruso, University of Palermo, Italy 🔗 Read the full article: https://lnkd.in/g3G9GYB8

📢 New Online special issue: Immunogenetics of Chronic Illnesses is open for submissions now!! Welcome join us and discuss this topic! 📰 Edited by Dr. Apostolos P. Georgopoulos & Dr. Lisa M. James, University of Minnesota, Minneapolis, USA 🎯 Human leukocyte antigen (HLA) plays a critical early role in the human immune response to foreign antigens such as viruses and bacteria and has been widely implicated in conferring risk for, or protection against, development of various health conditions. HLA genes code for cell-surface HLA molecules that bind with and present peptides of foreign antigen proteins to T cells, stimulating cellular and humoral immune system responses aimed at elimination of foreign antigens. Successful immune system responses to foreign antigens depends on binding affinity and immunogenicity of the peptide-HLA complex. However, HLA is the most highly polymorphic region of the human genome and even single amino acid differences in HLA alleles affect binding affinity and immunogenicity. In the case of HLA-peptide mismatch in which binding affinity and/or immunogenicity is low, foreign antigens may persist, contributing to chronic health conditions. Indeed, recent evidence points to the persistence of SARS-CoV-2 antigen in long-COVID, and other persistent antigens have been associated with chronic conditions including Lyme disease, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), and Gulf War Illness/Chronic Multisymptom Illness, among others. For various other chronic conditions, HLA has been implicated although evidence of antigen persistence is limited. The premise of this special issue is that HLA influences risk for chronic conditions via its role in foreign antigen elimination. As such, contributions related to HLA, chronic conditions, foreign antigen exposure and persistence, and their interrelationships are well-suited for this special issue. 🔑 Keywords: #Immunogenetics; Human Leukocyte Antigen (#HLA); Chronic Ilnesses #chronic #illness 📅 Submission deadline: July 31, 2025 💲 APC: No article processing charge 🔗 Link to get more details: https://lnkd.in/gRUJ3VeV

📢Newly Published Sharing: Association of genetic variations of interleukin-6 polymorphism (rs1800795) with susceptibility to Hashimoto’s thyroiditis in West Algerian population #OA 👥 Authors: Nawal Labiad, Moussa Messatfa, Youcef Bouali-Youcef, Houria Kadiri, Nardjess Ouikhlef 🔑 Keywords: Hashimoto's thyroiditis, IL-6, SNP, polymorphism, West Algeria #SNP #Hashimoto #thyroiditis 🎯 "Conclusions: This study reports no significant difference in IL-6 (-174 G/C) gene polymorphism at the allelic or the genotypic level between Hashimoto’s patients and the control group (P > 0.05). No association between the SNP IL-6 rs1800795 and susceptibility to Hashimoto’s thyroiditis in Western Algerian population." 👤 Academic editor: Margherita Sisto, University of Bari Medical School, Italy 🔗 Read More: https://lnkd.in/gzUSeFzJ

📢Newly Published Sharing: Current challenges in the modern male immune system #review 👥 Authors: Vladimir Klimov, Andrew Klimov 🔑 Keywords: #Male immune system, “sequestrated antigens”, self-tolerance, male infertility, sperm #allergy 🎯 "......The purpose of this review paper is to assess and interpret published data on the male immune system combined with the reproductive system, their influence on fertility rates, relatively new data on the role of the prepuce in the transmission of infections linked with sexual activity, new understanding of the composition of cells and molecules contributing to the maintenance of self-tolerance, and new disorders in the male immune system." 👤 Academic editor: Daishu Han, Chinese Academy of Medical Sciences & Peking Union Medical College, China 🔗 Read More: https://lnkd.in/gANcJRbP

📢Newly Published Sharing: The growing potential of tofacitinib in immune checkpoint inhibitor-induced colitis: identifying remaining puzzle pieces #review 👥 Authors: Raffaele Pellegrino, Giovanna Palladino, Giuseppe Imperio, Antonietta Gerarda Gravina 🔑 Keywords: Immune checkpoint inhibitors, colitis, immunotherapy, tofacitinib 🎯 "Immunotherapy, a primary anti-neoplastic treatment, exploits the patient’s immune system to kill neoplastic cells by modulating immune checkpoints such as cytotoxic T-lymphocyte antigen 4 and programmed cell death 1. Despite an apparent anti-neoplastic efficacy, immunotherapeutic agents are often accompanied by multiorgan toxicity, including gastrointestinal ones...." 👤 Academic editor: Cunte Chen, South China University of Technology, China 🔗 Read More: https://lnkd.in/gAuHbGhS

📚 Completed Special Issue Sharing | Immunobiology and Inflammation in the Male Reproductive System #Immunobiology 🧑 Edited by Dr. Daishu Han, Professor, Department of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China 🎯 This Special Issue aims to the current understanding of immune microenvironments, inflammatory diseases and therapeutic approaches in the MRS. The review and original articles in the fields are welcome to this special issue. #MRS 👏 Published 6 interesting papers on different preferences, including  ◾ NLRP3 inflammasomes  ◾ Maternal immune activation #maternal ◾ Testicular #inflammation ◾ Structure and function of the #epididymis ◾ Immune cell dynamics in male reproductive health ◾ Ningmitai #capsule 🎉 Weclome to read more: https://lnkd.in/gvaU3cFZ

📢Newly Published Paper Sharing: Plant derived bioactive compounds for the treatment of neurodegeneration and neuroimmune disorders associated with the complement system #review 👥 Authors: Jeyaparthasarathy Narayanaperumal, Ganesh Gopal 🔑 Keywords: #Complement systems, #neurodegeneration, neuroimmune disorders, #phytochemicals, #therapeutic 🎯 "......In this review, we summarized the current knowledge on the roles of the complement system in human neurodegenerative disorders and the benefits of natural compounds for complement-targeted therapy." 👤 Academic editor: Calogero Caruso, University of Palermo, Italy 🔗 Read the full article: https://lnkd.in/g3G9GYB8