Biomarker (BMKGENE) AMEA

Do you know that? 🐙 Octopus Intelligence: Octopuses have a truly unique genetic trait: about 60% of their RNA is edited after being transcribed from DNA. This allows octopuses to adapt to their environments at an unprecedented level. This form of RNA editing enables them to rapidly adjust the proteins their cells produce, helping them adapt quickly to complex environments. #FunFriday #KnowledgeChallenge #GeneSequencing #DNA

In the gene expression quantification analysis of RNA sequencing data, FPKM (Fragments Per Kilobase of transcript per Million mapped reads) is a commonly used unit for quantifying gene expression. FPKM values can be used to indicate the expression level of genes in samples, taking into account the effects of gene length and sequencing depth. When calculating FPKM values, the following steps are typically involved: 1. Calculate gene expression: Initially, determine the number of reads for each gene from the RNA-Seq sequencing data. 2. Normalization: Normalize the number of reads for each gene by dividing by the total number of mapped reads, calculated per million, to consider differences in sequencing depth between samples. 3. Consider gene length: Genes with longer lengths may capture more reads. Divide the normalized reads by the gene length in kilobases to obtain the number of reads per kilobase per million mapped reads. FPKM values can be used to compare the expression levels of different genes within the same sample or across different samples, as well as to observe changes in gene expression under different conditions. Due to its consideration of gene length and sequencing depth, FPKM is widely used in the quantitative analysis of RNA-Seq data. With advancements in technology, some studies also use alternative units such as TPM (Transcripts Per Million) to represent gene expression levels. BMKGENE can provide reliable transcriptome sequencing and professional bioinformatics analysis services for your research needs. #RNA #Transcriptome #GeneExpressionQuantification #FPKM

The article published in Theranostics, Klotho-derived peptide 1 inhibits cellular senescence in the fibrotic kidney by restoring Klotho expression via posttranscriptional regulation. Klotho deficiency is a common feature of premature aging and chronic kidney disease (CKD). As such, restoring Klotho expression could be a logic strategy for protecting against various nephropathies. 🔍 This study demonstrates that KP1, a Klotho-derived peptide, inhibits cellular senescence and induces Klotho expression via posttranscriptional regulation mediated by miR-223-3p and lncRNA-TUG1. By restoring endogenous Klotho, KP1 elicits a broad spectrum of protective actions and could serve as a promising therapeutic agent for fibrotic kidney disorders. 🦠 💡 #BMKGENE provided small RNA sequencing and bioinformatics analysis services for this study. #miRNA #Klotho #CellularSenescence #KidneyFibrosis

Celebrating National Pear Month: A Perfect Pairing of Innovation and Flavor 🍐🧬 As we celebrate National Pear Month this December, we're reminded of the versatility and richness of pears, much like the cutting-edge services we offer at BMKGENE. Just as pears come in various varieties—each offering unique flavors and textures—our high-throughput sequencing services bring a diverse range of solutions to meet your research needs in microbiome analysis, spatial transcriptomics, multi-omics, and more. 🔍 Pears are a natural fit for every meal—whether in savory dishes, baked desserts, or refreshing salads. Similarly, our sequencing services help uncover the hidden "flavors" of your data, revealing insights that support breakthroughs in biology, medicine, and environmental science. Just as you can enhance a dish with the subtle sweetness of pears, our high-throughput sequencing enhances your research by providing detailed, actionable data to inform your next discovery. From analyzing complex microbiomes to exploring spatial gene expression, our services help you unlock the full potential of your samples. 🍐 This National Pear Month, whether you're experimenting in the kitchen or conducting groundbreaking research, let's embrace the power of discovery. At BMKGENE, we're committed to providing the precision and innovation you need to explore the "ingredients" of life, just as pears bring an extra touch of flavor and health to every meal. 🍲 #NationalPearMonth #BiotechInnovation #SequencingServices #Microbiome #SpatialTranscriptomics #MultiOmics #ResearchExcellence #SavorTheSeason #ScienceAndFlavor

**Celebrating International Tea Day: Advancing Tea Plant Research Through Biotechnology** On International Tea Day, we celebrate both the rich cultural heritage of tea and the innovations in biotechnology that are shaping its future. Tea, one of the world’s most consumed beverages, holds immense genetic diversity across its varieties. At BMKGENE, we are proud to contribute to the evolving field of tea research using high-throughput sequencing to unlock the genetic secrets of the *Camellia sinensis* plant. 🌱 Our work, including one key publication—**"The reference genome of tea plant and resequencing of 81 diverse accessions: Insights into genome evolution and adaptation of tea plants"**—has provided critical insights into the genetic makeup of tea plants. By sequencing 81 different tea accessions, we’ve gained a deeper understanding of how tea plants adapt to various environmental conditions. This research not only advances our knowledge of tea plant evolution but also opens doors for improving disease resistance, yield, and climate resilience through genomics 🧬. High-throughput sequencing is a game-changer in identifying the genetic traits that affect tea quality and growth. These insights are crucial for breeding more resilient and productive tea plants, helping farmers 🧑🌾 mitigate the impacts of climate change while ensuring sustainable production. As we honor the tradition of tea, we also look forward to the future—where scientific advancements continue to enhance both the sustainability and quality of tea farming worldwide 🌏. #InternationalTeaDay #TeaResearch #Biotechnology #HighThroughputSequencing #TeaGenomics #Sustainability #InnovationInAgriculture

🎉 Celebrating National Poinsettia Day: Beauty, Tradition, and Innovation in Horticulture 🌿🎄 On National Poinsettia Day, we celebrate the vibrant beauty 🌺 and rich cultural significance of the poinsettia, a holiday favorite that symbolizes the season's joy ✨. Native to Mexico 🇲🇽 and introduced to the U.S. by Joel Poinsett in the 1800s, the poinsettia has become one of the most popular plants worldwide, especially during the Christmas season 🎅🎁. As a company at the forefront of agricultural innovation 🌱, BMKGENE recognizes the important role biotechnology plays in improving poinsettia cultivation. From enhancing disease resistance to optimizing growing conditions 🌞, modern biotechnological advances are enabling more efficient, sustainable production. Genetic research and improved breeding methods are also leading to new varieties and color patterns, meeting consumer demand while ensuring plant health. Sustainability is also key to the future of poinsettia production 🌎💧. With a growing focus on eco-friendly practices 🌱, growers are adopting water-efficient techniques, reducing pesticide use, and using energy-efficient technologies to lower their environmental impact. On this special day, we celebrate not only the poinsettia's beauty and tradition but also the role of innovation 💡 in ensuring these beloved plants thrive for generations to come 🌿. #NationalPoinsettiaDay #Sustainability #HorticultureInnovation #Biotechnology #PlantScience #Poinsettias #HolidaySeason #AgriculturalInnovation

Wide-targeted metabolomics in plants combines the advantages of non-targeted high-resolution and broad coverage techniques with the sensitivity and precise quantification capabilities of targeted multiple reaction monitoring (MRM) methods. By utilizing high-resolution mass spectrometry for comprehensive secondary scan coverage of all metabolites, followed by accurate identification through a vast high-resolution secondary spectrum database, specific MRM ion pairs are extracted to establish sample-specific libraries. Subsequently, triple quadrupole mass spectrometry is employed for precise quantification. This integrated approach offers numerous technical advantages, including extensive substance identification, precise qualitative and quantitative analysis, wide dynamic range, high sensitivity, and excellent reproducibility. #BMKGENE provides services in plant-wide-targeted metabolomics, non-targeted metabolomics, targeted metabolomics, offering a highly efficient method for detecting complex plant metabolites. #PlantMetabolomics #BMKGENE #MetabolomicsServices

👏 Another Success Story in BMKGENE's Genomics Database Construction! Exciting news today as our client's groundbreaking work was published in the prestigious journal Nucleic Acids Research, showcasing their achievement in establishing the "MolluscDB 2.0", a cutting-edge functional and evolutionary genomics database encompassing over 1400 molluscan species. This exceptional database integrates a wealth of over 4200 multi-omics data resources across various mainstream omics dimensions, including high-quality genomes, bulk transcriptomes, single-cell transcriptomes, proteomes, epigenomes, and microbial metagenomes. The molluscan multi-omics resources cover 92% of the eight orders and 76 families within the Mollusca phylum, spanning diverse environments from land, freshwater, nearshore, to deep-sea regions. Furthermore, it offers a range of tools for genomic comparative analysis. BMKGENE played a pivotal role in the establishment of this groundbreaking international molluscan comprehensive genomics database, MolluscDB. 🦠 In recent years, the growth of functional genomics data has been exponential, underscoring the importance of systematic integration and in-depth analysis of vast multi-omics resources. By customizing analysis platforms tailored to species-specific characteristics, efficient utilization of omics data is achievable, providing robust support for gene resource exploration and genetic breeding efforts. #BMKGENE has successfully collaborated in constructing genomics databases for multiple species, boasting a wealth of experience in this domain. If you're considering consolidating genomic data for your species of interest, we welcome you to reach out to us for more information! #BioinformaticsDatabase #BMKGENE #MultOmics #BigData #Genomics

🦠 In microbiology and biodiversity studies, amplicon sequencing is a commonly used technique for analyzing the composition and structure of microbial communities. Researchers typically select the 16S, 18S, and ITS (Internal Transcribed Spacer) regions for amplicon sequencing for the following reasons: 🔍 The 16S rRNA gene is widely present in the genomes of the majority of bacteria and archaea, serving as a common feature of these microorganisms. The sequence of the 16S rRNA gene is highly conserved across different bacteria and archaea, yet contains sufficient variability to distinguish between different microbial species. The 18S rRNA gene is commonly found in eukaryotes, representing a shared characteristic of these organisms. 🔍 The ITS region (Internal Transcribed Spacer) exhibits high variability in bacteria, archaea, and eukaryotes, making it suitable for studying relationships between species. ITS sequences offer high resolution for species-level identification and classification, aiding in the differentiation of various microbial species. Therefore, targeting the 16S, 18S, and ITS regions for amplicon sequencing enables a comprehensive and in-depth understanding of microbial communities, assisting researchers in uncovering the diversity, structure, and functionality of these communities. The selection of these regions is based on their distinct characteristics and widespread utility across different biological domains. #BMKGENE can provide NGS and full-length amplicon sequencing services, to meet the research needs of researchers. #Amplicon #Microbiology #Biodiversity #16S #18S #ITS

**World Wildlife Conservation Day: A Call to Protect Our Planet's Biodiversity** Today, on #WorldWildlifeConservationDay, we reflect on the critical state of our planet's biodiversity and the urgent need to protect the rich variety of life that surrounds us. 🌱 🌏 As a biotechnology company focused on plant and animal sequencing, we believe it is essential to harness the power of science and innovation to help safeguard our planet’s biodiversity. By understanding the genetic makeup of both plant and animal species, we can gain critical insights into how to protect them from the many threats they face, from habitat destruction to disease outbreaks. 🌿 At BMKGENE, we are committed to advancing the science of genomics to protect and preserve biodiversity. By sequencing the DNA of both plants and animals, we can identify genetic markers that help us understand their health, behavior, and potential vulnerabilities. This knowledge is key to informing conservation efforts, improving breeding programs for endangered species, and even restoring ecosystems that have been damaged by human activity. 🌻 🦋 Biotechnology also offers tools to help mitigate the human impact on wildlife, from developing sustainable agriculture practices that protect natural habitats to finding ways to fight diseases that threaten species populations. The potential to use science to protect the planet's biodiversity is vast, and we are proud to be part of that effort. #WorldWildlifeConservationDay #Biodiversity #Conservation #WildlifeProtection #Biotechnology #GenomicsForGood #SustainableFuture #ProtectOurPlane