Mike Martin

🔬🧪KL #Research Update🚀 How are depression and anxiety portrayed in mainstream and social media? See open access scoping review by the Transitional Psychiatry Research Centre Wie werden Depressionen und Angstzustände in den sozialen und den Mainstream-Medien dargestellt? Siehe Open Access Scoping Review des Transitional Psychiatry Research Centre ➡️ bit.ly/4dlr31p

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New paper published in #SpecialIssue "Midwifery-Led Care and Practice: Promoting Maternal and Child Health" edited by Dr. Joachim Graf and written by the guest editor himself: Enabling to breastfeed is the public health key for promoting women's health!

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A very insightful read and well-written comparison of postpartum care models. I hope this article encourages some much needed discussion regarding opportunities for improvement in U.S. postpartum care delivery!

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Chronic illnesses affect the well-being of both the person with the illness and their relatives, but much less is known on 🥺 who in families needs what kind of help? 🛠️ who has ressources in (which kind of) families? 🍜 how does it affect family life? 🧑‍🧒 what do we mean by 'family' anyhow when doing research? #ChronicIllness #Caregivers #NewPerspectives #Careum 👇🏽 We would like to hear your thoughts, experiences and ideas

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🚀 I am thrilled to add another piece to the “ONECUT1 diabetes” puzzle, again with joint forces between the #JulierLab at #INSERM and the collaborative efforts #IvanCosta from #RWTHAACHEN, the Institutes of #HumanGenetics and #TransfusionMedicine at #UlmUniversity, and many other supportive collaborators! Our journey began with characterizing the regulatory patterns of ONECUT1 (OC1) during pancreatic lineage commitment, published in #CommunicationsBiology (https://lnkd.in/eCNn2-bn). We then discovered that OC1 coding mutations are associated with various forms of diabetes, including monogenic recessive syndromic diabetes and early-onset nonautoimmune diabetes, revealing its critical role in pancreatic development and diabetes pathogenesis, as detailed in #NatureMedicine (https://lnkd.in/enDpaGsJ). Building on this foundation, we're excited to announce our latest publication in #CellReports! Brilliant Sarah Merz completed her PhD with her second first authorship under the guidance of #SandraHeller, alongside #CecileJulier and me (https://lnkd.in/e2qDJQkp). We identified a disease-causing deletion upstream of OC1 in compound heterozygosity with an OC1 mutation in an affected individual, while investigating its functional role as a cis-acting enhancer influencing OC1 expression during pancreatic development. We also explored in vitro therapeutic options for affected patients and linked a low-frequency variant to type 2 diabetes. Excitingly, the #DanweiHuangfuLab utilized CRISPRi screening during pancreatic differentiation, confirming our findings regarding the same enhancer. A special thanks to #MaureenGannon for summarizing both our studies in a fantastic preview article in #CellReports titled “CUTting through the distance - A disease-relevant long-range ONECUT1 enhancer.” https://lnkd.in/eM3k3VA8. Your support is invaluable! As Sarah Merz moves on to a postdoc with #DiegoBalboa at the #UniversityofHelsinki, we are excited to announce that we are recruiting the next generation of PhD students to join our successful team at #IMOS! 🌟 Let’s continue pushing the boundaries of diabetes research together! https://lnkd.in/eysHJnwF

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Very interesting and important findings from scientists at The Max Planck Institue of Psychiatry in Munich, Germany, that there is a link between pupil response and loss of pleasure. This discovery contributes to a better understanding of the physiological mechanisms behind depression. Therefore, #pupillometry could be used as a supplementary method for #diagnosis of depression. It could contribute to the development of individualized treatment strategies for depression. For example, if a patient shows a significantly reduced pupil response, #antidepressants that act on the noradrenergic system could be more effective than other medications. The medication dosage could also be optimized based on the pupil reaction. The pupillary reaction is a marker for activity in the locus coeruleus, the #brain structure with the highest concentration of noradrenergic neurons in the #centralnervoussystem. Noradrenergic neurons react to the neurotransmitter #norepinephrine, an important component in the #stress response and the upregulation of arousal, in other words, the activation of the nervous system, and play a role in #depression and listlessness. #MentalHealthAwarenessMonth #psychiatry #biomarkers #depression

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New article with Carol Clymer, Beth Grinder Mclean, and Jungeun Lee! Parents’ learning in family literacy: A mixed-methods evaluation. https://lnkd.in/eTPGpics It's part of a special journal issue of Zeitschrift für Weiterbildungsforschung (Journal for Research on Adult Education) that Carol and I co-edited with colleagues. This article is based on 5-year evaluation of the William Penn Foundation's Family Literacy Initiative in Philadelphia. It's one of the few articles to discuss how *parents* (rather than children) learn and benefit from participating in family literacy. Fun fact: the survey was translated into 12 languages. Abstract: In the USA, comprehensive family literacy programs integrate adult education and parent education, interactive parent-child literacy activities, and early childhood education or school for children. Although parents’ learning is central to family literacy, research overwhelmingly focuses on children’s outcomes or positions parents as conduits of children’s learning. Thus, we know little about changes in parents’ language and literacy capabilities, self-concepts, social support systems, or other benefits. This study reports findings from a multi-year, mixed-methods evaluation of five family literacy programs in Philadelphia, Pennsylvania. Participants were primarily immigrant mothers. Qualitative data, along with statistically significant quantitative data from a pre-post survey (n=139), demonstrate learning in four domains: educational, personal, social, and parenting. Specifically, parents developed literacy and language skills; enjoyed reading more and spent more time reading alone and with children; were more involved in everyday literacy practices; increased their self-confidence and self-esteem; provided support for each other, developed friendships, and built a sense of community; and increased support for and involvement in their children’s development, literacy, and education. These results build on prior research on parental outcomes and illustrate the value of using multifaceted, holistic measures to examine how parents benefit from family literacy.

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📰 New Paper 📣 Led by Nicolas Wrede, we have tested a cognitive vulnerability-stress model of #depression and #anxiety in family #caregivers of people with #dementia. The relation between objective demands and subjective burden was amplified by dysfunctional caregiving standards and dysfunctional attitudes towards dementia and mitigated by functional self-care-related beliefs. Further, functional acceptance-related beliefs attenuated the effect of subjective caregiver burden on depression. Open Access 🔓 https://lnkd.in/ek_Ny26h

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NEW Journal of Neuroendocrinology Special Issue: A Festschrift for Robert Millar In this Special Issue we celebrate the career of Professor Bob Millar with a series of original and review articles, many open access, that came out of Bob's Festschrift held in South Africa, February 2024. Articles include: - A career in numbers: A citation network analysis of the work of RP Millar and his contribution to GnRH research - Kisspeptin and neurokinin B neuroendocrine pathways in the control of human ovulation (open access) - Novel insights into minipuberty and GnRH: Implications on neurodevelopment, cognition and COVID-19 therapeutics (open access) - Does the brain make prolactin? (open access) - The role of neuroestrogens in the estrogen-induced gonadotropin surge in male monkeys (open access) - Estradiol action in the female hypothalamo-pituitary-gonadal axis (open access) Read the full Special Issue: https://lnkd.in/ejJg6JRv Members of the British Society for Neuroendocrinology can also access the original talks from the Festschrift on the members-only website, mySociety.

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I am happy to share news of the publication of our German validation study of the International Trauma Interview (ITI) in the European Journal of Psychotraumatology: https://lnkd.in/dVsrksTD The ITI is a structured clinical interview for the diagnosis of ICD-11 posttraumatic stress disorder (PTSD) and complex posttraumatic stress disorder (CPTSD). This is the first clinical study to validate the ITI among trauma-exposed in-and outpatients with high prevalence rates of PTSD and CPTSD. Many thanks to the research team and co-authors from five primary care psychotherapeutic centers in Switzerland and Germany: Andreas Maercker, yafit levin, Kai Köhler, Gerd Willmund, Martin Bohus, Stefanie Koglin, Stefan Röpke, Nikola Schoofs, Kathleen Priebe, Felix Wülfing, Christian Schmahl, Manuel P. Stadtmann, Heinrich Rau, Dr. Mareike Augsburger #mentalhealth #ICD-11 #diagnostic #research #psychology

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Psychoanalysis On and Off the Couch #164: Transformation of Dreams in Analysis: the Research Findings with Marianne Leuzinger-Bohleber, Prof. Dr. Phil. (Frankfurt) "In my own two analyses, I had observed such transformations for me in a very impressive way. I started my own analysis after the traumatic death of my sister when I was 22 years old. At that time, I had a breakdown, and I suffered from severe depressive and psychosomatic symptoms and sleep disorders but also from terrible nightmares that haunted me almost every night. Fortunately, my two analyses did change my depressive and psychosomatic symptoms, but what was at least as important for me, subjectively, was the change in my dreams, including the manifest dream content. The nightmares became less frequent; I was hardly in the position of an observer anymore but actively involved in the dream event. I was less alone in the dream but accompanied by people close to me and was more often able to solve the problems and conflicts which arose in the dream. In addition, the dreams were no longer predominantly characterized by fear and death anxiety but a whole range of emotions emerged. Towards the end of my second analysis, I will never forget that I had the only dream of my life from which I woke up because I was laughing out loud." Episode Description: We begin with acknowledging the ambivalence that many analysts have towards research. It is seen as distant from the sharing of subjectivities that draw many to our field. Marianne honors the unique transference reliving and then remembering that is central to the analytic encounter and from that position suggests ways that it can be researched. She presents a patient whose manifest dreams were studied over the course of treatment along with his sleep laboratory data. She notes how the stability of the analyst's presence is essential but not sufficient to maximize therapeutic benefit. We discuss the role of theory, the controversy over approaching the veridical past and the seductions of simplified treatments. Marianne closes by sharing her deep respect for the unconscious and how psychoanalysts are living in "rich times of pluralism." Linked Episode:  https://lnkd.in/ea-Y_NzQ IPAOfftheCouch.org Upcoming Episode (September 5th): An Analyst's Journey with Cancer with Jhuma Basak, PhD (Calcutta) https://lnkd.in/eArP9cYB

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The Veracity Function: Integrity and Comprehensiveness of Evidence https://lnkd.in/gsvTyJ6N

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Recontextualising Psychological Interventions in the Outdoors (9 open access outdoor therapy papers on mental health, family and school-based interventions, depression, rehabilitation, ethics and #nature connection). For those interested in developing #outdoortherapy interventions. #FrontiersinPsychology special issue. #naturebasedtherapy #adventuretherapy #wildernesstherapy #mentalhealth https://lnkd.in/gR66MfvB

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#ERS2024 Day 2: co-chairing with (the always inspiring) Prof. Andrew Bush the studio session "Little Humans & Machines: getting the balance right in childhood asthma". Together with 2 great speakers (Dr. David Drummond & Dr. Giuliana Ferrante) we explored the exciting and fast-growing world of digital health technologies in childhood asthma care—covering mobile apps, telemonitoring, and even social robots! Key lesson: ➡️ Digital tools are promising, but one size doesn't fit all. We must carefully evaluate which technologies work best for each child, ensuring it fits their needs! #DigitalHealth #ChildhoodAsthma #PersonalizedCare #Pediatrics #Telemedicine  

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