About
• Specialist in DNA engineering and synthetic biology (PhD since 1993). Inventor of…
Articles by Philippe
Activity
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Proteon Pharmaceuticals is delighted to announce that the Ministry of Agriculture, Livestock Farming, and Supplies (MAPA) in Brazil has registered…
Proteon Pharmaceuticals is delighted to announce that the Ministry of Agriculture, Livestock Farming, and Supplies (MAPA) in Brazil has registered…
Liked by Philippe Gabant, PhD
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New publication led by Garreth Lawrence with Enriqueta Garcia-Gutierrez Katie O'Mahony (Falà) Calum Walsh Máire Begley & Caitriona Guinane in…
New publication led by Garreth Lawrence with Enriqueta Garcia-Gutierrez Katie O'Mahony (Falà) Calum Walsh Máire Begley & Caitriona Guinane in…
Liked by Philippe Gabant, PhD
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✨ Exciting milestone in my PhD journey! ✨ I am thrilled to share that I presented my first-ever poster at the Namur Research Institute for Life…
✨ Exciting milestone in my PhD journey! ✨ I am thrilled to share that I presented my first-ever poster at the Namur Research Institute for Life…
Liked by Philippe Gabant, PhD
Experience
Education
Publications
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Protein Bioproduction without Antibiotics
GEN Oct 15, 2011 (Vol. 31, No. 18)
A short review on using Toxin-Antidote as an alternative to antibiotic resistance markers.
Other authorsSee publication -
The art of selective killing: plasmid toxin/antitoxin systems and their technological applications.
Biotechniques. 2008 Sep;45(3):344-6. doi: 10.2144/000112955.
Review:
Technologies using recombinant DNA have become of paramount importance in most biology laboratories today and plasmid toxin/antitoxin (T/A) systems have proven to be very useful by facilitating different key technologies of molecular cloning. Several applications and the underlying technologies are highlighted in this review.Other authorsSee publication -
Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility.
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12865-70. Epub 2002 Sep 24
First mammalian model to discover Alpha-fetoprotein function. The alpha-fetoprotein gene (Afp) is a member of a multigenic family that comprises the related genes encoding albumin, alpha-albumin, and vitamin D binding protein. The biological role of this major embryonic serum protein is unknown although numerous speculations have been made. We have used gene targeting to show that AFP is not required for embryonic development. AFP null embryos develop normally, and individually transplanted…
First mammalian model to discover Alpha-fetoprotein function. The alpha-fetoprotein gene (Afp) is a member of a multigenic family that comprises the related genes encoding albumin, alpha-albumin, and vitamin D binding protein. The biological role of this major embryonic serum protein is unknown although numerous speculations have been made. We have used gene targeting to show that AFP is not required for embryonic development. AFP null embryos develop normally, and individually transplanted homozygous embryos can develop in an AFP-deficient microenvironment. Whereas mutant homozygous adult males are viable and fertile, AFP null females are infertile. Our analyses of these mice indicate that the defect is caused by a dysfunction of the hypothalamic/pituitary system, leading to anovulation.
Other authorsSee publication -
Use of the ccdB killer gene for construction of positive selection vectors
Gene 1994, Vol 148, p71-74
First publication describing ccdB gene for the selection of recombinant vectors. This selection is today a standard in molecular cloning.
Other authors
Patents
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Controlled growth of microorganisms
Issued US Patent US 9,333,227
Technology for the control of microbial strains based on bacteriocins loci.
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METHOD FOR THE SELECTION OF RECOMBINANT CLONES COMPRISING A SEQUENCE ENCODING AN ANTIDOTE PROTEIN TO A TOXIC MOLECULE
Issued EU WO 2002/066657
Patent describing the use of antidote gene function to select for recombinants.
Other inventorsSee patent -
Cloning and/or sequencing vector
Issued US US 5,910,438
Selection technology based on the natural ccdB gene. Licensed to Life technologies (Invitrogen) since 1995. Products on the market under licence: TOPO, GATEWAY vectors. Today a standard to select recombinant vectors.
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Languages
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French
Native or bilingual proficiency
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English
Full professional proficiency
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Flemish
Elementary proficiency
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Italian
Elementary proficiency
More activity by Philippe
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Happy holidays everyone! We had a great celebration with my lab, including Secret Santa, and a fantastic quiz by Oliver Konzock! We also had some…
Happy holidays everyone! We had a great celebration with my lab, including Secret Santa, and a fantastic quiz by Oliver Konzock! We also had some…
Liked by Philippe Gabant, PhD
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Avant que l'année ne se termine, l'équipe d'Innodal aimerait vous souhaiter de joyeuses fêtes ! Nous tenons également à vous remercier tous pour…
Avant que l'année ne se termine, l'équipe d'Innodal aimerait vous souhaiter de joyeuses fêtes ! Nous tenons également à vous remercier tous pour…
Liked by Philippe Gabant, PhD
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🎄 𝐌𝐞𝐫𝐫𝐲 𝐂𝐡𝐫𝐢𝐬𝐭𝐦𝐚𝐬 𝐚𝐧𝐝 𝐇𝐚𝐩𝐩𝐲 𝐍𝐞𝐰 𝐘𝐞𝐚𝐫 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞 𝐄𝐄𝐛𝐢𝐨 𝐓𝐞𝐚𝐦! 🎉 Last week, all the EEBio postdocs, three…
🎄 𝐌𝐞𝐫𝐫𝐲 𝐂𝐡𝐫𝐢𝐬𝐭𝐦𝐚𝐬 𝐚𝐧𝐝 𝐇𝐚𝐩𝐩𝐲 𝐍𝐞𝐰 𝐘𝐞𝐚𝐫 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞 𝐄𝐄𝐛𝐢𝐨 𝐓𝐞𝐚𝐦! 🎉 Last week, all the EEBio postdocs, three…
Liked by Philippe Gabant, PhD
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🚀 Exciting milestone for #phages! INFARMED, I.P. has officially approved the use of phage therapy in Portugal. This groundbreaking decision allows…
🚀 Exciting milestone for #phages! INFARMED, I.P. has officially approved the use of phage therapy in Portugal. This groundbreaking decision allows…
Liked by Philippe Gabant, PhD
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Bacteria have multiple layers of defense against phage infection, both inside and outside the cell. One such mechanism is abortive infection, or Abi.…
Bacteria have multiple layers of defense against phage infection, both inside and outside the cell. One such mechanism is abortive infection, or Abi.…
Liked by Philippe Gabant, PhD
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Antimicrobial resistance once again strikes one the world's poorest region. This should be a major concerns for our leaders. A lot of initiative…
Antimicrobial resistance once again strikes one the world's poorest region. This should be a major concerns for our leaders. A lot of initiative…
Liked by Philippe Gabant, PhD
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The 5th edition of #NGSB24 united academia & industry to explore the latest in #SyntheticBiology - from AI to living materials. Discover key…
The 5th edition of #NGSB24 united academia & industry to explore the latest in #SyntheticBiology - from AI to living materials. Discover key…
Liked by Philippe Gabant, PhD
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Just came back from the Next Generation Synthetic Biology 2024 conference organized by VIB , what an absolute blast! 💥 Among talks from the usual…
Just came back from the Next Generation Synthetic Biology 2024 conference organized by VIB , what an absolute blast! 💥 Among talks from the usual…
Liked by Philippe Gabant, PhD
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Full room in the European Parliament yesterday and more than 100 participants onlie 👏👏👏 following the High-Level debate on „Potential of…
Full room in the European Parliament yesterday and more than 100 participants onlie 👏👏👏 following the High-Level debate on „Potential of…
Liked by Philippe Gabant, PhD
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Interesting workshop about Phage Banks in #Bruges, Belgium. This workshop was organized by the not-for-profit organization Phages for Human…
Interesting workshop about Phage Banks in #Bruges, Belgium. This workshop was organized by the not-for-profit organization Phages for Human…
Liked by Philippe Gabant, PhD
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I will be speaking Sustainable Foods Foods Conference, on the 28th January as part of a dedicated panel titled ‘Planting the Future: Strategies for…
I will be speaking Sustainable Foods Foods Conference, on the 28th January as part of a dedicated panel titled ‘Planting the Future: Strategies for…
Liked by Philippe Gabant, PhD
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It’s been an exciting day yesterday! I am so proud to see, that the #phage community is gaining on recognition among EU decision makers and…
It’s been an exciting day yesterday! I am so proud to see, that the #phage community is gaining on recognition among EU decision makers and…
Liked by Philippe Gabant, PhD
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