Philippe Gabant, PhD

Philippe Gabant, PhD

Brussels Metropolitan Area
2K followers 500+ connections

About

• Specialist in DNA engineering and synthetic biology (PhD since 1993). Inventor of…

Articles by Philippe

  • DNA based toys kits

    DNA based toys kits

    DNA toys kits for children. It contains DNA molecules to generate perfume…if you have kids a novel idea for a birthday…

Activity

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Experience

Education

Publications

  • Protein Bioproduction without Antibiotics

    GEN Oct 15, 2011 (Vol. 31, No. 18)

    A short review on using Toxin-Antidote as an alternative to antibiotic resistance markers.

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  • The art of selective killing: plasmid toxin/antitoxin systems and their technological applications.

    Biotechniques. 2008 Sep;45(3):344-6. doi: 10.2144/000112955.

    Review:
    Technologies using recombinant DNA have become of paramount importance in most biology laboratories today and plasmid toxin/antitoxin (T/A) systems have proven to be very useful by facilitating different key technologies of molecular cloning. Several applications and the underlying technologies are highlighted in this review.

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  • Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility.

    Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12865-70. Epub 2002 Sep 24

    First mammalian model to discover Alpha-fetoprotein function. The alpha-fetoprotein gene (Afp) is a member of a multigenic family that comprises the related genes encoding albumin, alpha-albumin, and vitamin D binding protein. The biological role of this major embryonic serum protein is unknown although numerous speculations have been made. We have used gene targeting to show that AFP is not required for embryonic development. AFP null embryos develop normally, and individually transplanted…

    First mammalian model to discover Alpha-fetoprotein function. The alpha-fetoprotein gene (Afp) is a member of a multigenic family that comprises the related genes encoding albumin, alpha-albumin, and vitamin D binding protein. The biological role of this major embryonic serum protein is unknown although numerous speculations have been made. We have used gene targeting to show that AFP is not required for embryonic development. AFP null embryos develop normally, and individually transplanted homozygous embryos can develop in an AFP-deficient microenvironment. Whereas mutant homozygous adult males are viable and fertile, AFP null females are infertile. Our analyses of these mice indicate that the defect is caused by a dysfunction of the hypothalamic/pituitary system, leading to anovulation.

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  • Use of the ccdB killer gene for construction of positive selection vectors

    Gene 1994, Vol 148, p71-74

    First publication describing ccdB gene for the selection of recombinant vectors. This selection is today a standard in molecular cloning.

    Other authors
    • Philippe Bernard
    • Martine Couturier
    • Mohamed El Bahassi
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Patents

Languages

  • French

    Native or bilingual proficiency

  • English

    Full professional proficiency

  • Flemish

    Elementary proficiency

  • Italian

    Elementary proficiency

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