Jacob Goodwin

Jacob Goodwin

Clayton, Victoria, Australia
506 followers 481 connections

About

I am the Head of Innovation at Magic Valley, a startup that is producing cultivated meat…

Activity

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Experience

  • Magic Valley Graphic

    Magic Valley

    Melbourne, Victoria, Australia

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    Melbourne, Victoria, Australia

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    Melbourne, Victoria, Australia

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    Melbourne, Australia

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    Stockholm, Sweden

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    Gold Coast

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    Gold Coast, Australia

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Education

  • Griffith University Graphic

    Griffith University

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    During my PhD, I focused on how age related factors in neurobiology act synergistically to generate high molecular weight alpha-synuclein aggregates, similar to those seen in Parkinson's disease patients.

    This project involved the characterisation of alpha-synuclein oligomeric structures in vitro using recombinant protein and scanning electron microscopy, along with a cell culture model using confocal microscopy to assess the aggregation of alpha-synuclein in response to increased…

    During my PhD, I focused on how age related factors in neurobiology act synergistically to generate high molecular weight alpha-synuclein aggregates, similar to those seen in Parkinson's disease patients.

    This project involved the characterisation of alpha-synuclein oligomeric structures in vitro using recombinant protein and scanning electron microscopy, along with a cell culture model using confocal microscopy to assess the aggregation of alpha-synuclein in response to increased intracellular calcium and oxidative stress, two factors that increase in the brain as we age.

    The outcome of this research was two first author, two co-author research publications and one review article.

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    Activities and Societies: The Molecular Sciences Society

    This project involved the development of a Drosophila model system of Nijmegen Breakage Syndrome (NBS). Mutations in the NBS1 gene result in impaired DNA double strand break repair. NBS1 mutants were inserted into full length wt-NBS1construct +/-GFP in plasmids allowing for either embryonic or adult expression of protein constructs. Constructs were used to generate transgenic Drosophila lines expressing mutant NBS1 proteins, to cross with NBS1 null drosophila to assess the viability of…

    This project involved the development of a Drosophila model system of Nijmegen Breakage Syndrome (NBS). Mutations in the NBS1 gene result in impaired DNA double strand break repair. NBS1 mutants were inserted into full length wt-NBS1construct +/-GFP in plasmids allowing for either embryonic or adult expression of protein constructs. Constructs were used to generate transgenic Drosophila lines expressing mutant NBS1 proteins, to cross with NBS1 null drosophila to assess the viability of Drosophila as a model for NBS.

Licenses & Certifications

Volunteer Experience

  • Griffith University, Australia Graphic

    Siemans Science day demonstrator

    Griffith University, Australia

    - Present 14 years

    Education

    I was a demonstrator at the Siemans Science day at Griffith University where we took early high school students and gave them practical laboratory experiences to promote science as a career path.

  • Karolinska Institutet Graphic

    Biomedicum Social committee member

    Karolinska Institutet

    Science and Technology

    A new research center is currently being constructed at Karolinska Institutet that will house 5 different departments that have previously been working in isolation. At the Biomedicum research building all departments will be housed together to increase the collaborative work environment and to improve scientific discourse.

    I was involved in planing and running a Biomedicum social event to facilitate meeting and encourage interaction between the 5 departments before the move in 2018.

Publications

Languages

  • English

    Native or bilingual proficiency

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